N-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-5-(methylthio)pyrimidin-4-amine

Base Information

Chemical Name:N-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-5-(methylthio)pyrimidin-4-amine
CAS No.:1606178-64-6
Molecular Formula:C₁₅H₁₇BrClN₃S
Molecular Weight:386.743
Hs Code.:

Synonyms:N-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-5-(methylthio)pyrimidin-4-amine

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Chemical Property of N-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-5-(methylthio)pyrimidin-4-amine

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Technology Process of N-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-5-(methylthio)pyrimidin-4-amine

There total 4 articles about N-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-5-(methylthio)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1606178-58-8
6-((2-bromo-4-isopropylphenyl)amino)-2-methyl-5-(methylthio)pyrimidin-4(3H)-one

: 1606178-64-6
N-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-5-(methylthio)pyrimidin-4-amine

Guidance literature:: With trichlorophosphate; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2014.03.040

Reference yield:

: 246166-33-6
2-bromo-4-isopropylphenylisothiocyanate

: 1606178-64-6
N-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-5-(methylthio)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; sulfur / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C / Inert atmosphere

2.1: Reflux; Inert atmosphere

3.1: sodium hydroxide / 100 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: trichlorophosphate / Inert atmosphere; Reflux

With sulfur; triethylamine; sodium hydroxide; trichlorophosphate; In dimethyl sulfoxide; 1.1: |Gewald Aminoheterocycles Synthesis / 1.2: |Gewald Aminoheterocycles Synthesis;
DOI:10.1016/j.ejmech.2014.03.040

Reference yield:

: 228254-23-7
4-amino-3-(2-bromo-4-isopropylphenyl)-2-thioxo-2,3-dihydrothiazole-5-carboxamide

: 1606178-64-6
N-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-5-(methylthio)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Reflux; Inert atmosphere

2.1: sodium hydroxide / 100 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: trichlorophosphate / Inert atmosphere; Reflux

With sodium hydroxide; trichlorophosphate;
DOI:10.1016/j.ejmech.2014.03.040