Technology Process of (S)-2-(2-(3-ethyl-2,4-dimethyl-1H-indol-1-yl)acetamido)-N-(6-methoxypyridin-3-yl)-N-methyl-3-phenylpropanamide
There total 6 articles about (S)-2-(2-(3-ethyl-2,4-dimethyl-1H-indol-1-yl)acetamido)-N-(6-methoxypyridin-3-yl)-N-methyl-3-phenylpropanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; sodium nitrite / tin(ll) chloride / water / -5 - 5 °C
1.2: pH > 11
2.1: sodium hydrogencarbonate / dichloromethane / 3 h / 20 °C
2.2: 140 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
4.1: sodium hydride / methanol; dichloromethane; mineral oil / 1.83 h / 0 °C
4.2: 0.5 h / 20 °C
4.3: pH 4
5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium nitrite;
tin(ll) chloride;
In
tetrahydrofuran; methanol; dichloromethane; water; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrazine hydrate / Raney Nickel / methanol / 2 h / 20 °C
2.1: hydrogenchloride; sodium nitrite / tin(ll) chloride / water / -5 - 5 °C
2.2: pH > 11
3.1: sodium hydrogencarbonate / dichloromethane / 3 h / 20 °C
3.2: 140 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
5.1: sodium hydride / methanol; dichloromethane; mineral oil / 1.83 h / 0 °C
5.2: 0.5 h / 20 °C
5.3: pH 4
6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium nitrite;
tin(ll) chloride;
In
tetrahydrofuran; methanol; dichloromethane; water; mineral oil;
