(Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

Base Information

Chemical Name:(Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester
CAS No.:327027-77-0
Molecular Formula:C₅₁H₇₀O₈Si₂
Molecular Weight:867.283
Hs Code.:

(Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

Synonyms:(Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

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Chemical Property of (Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

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Technology Process of (Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

There total 1 articles about (Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: (Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-11-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

: 327027-77-0
(Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃;
DOI:10.1021/ol000342+

Reference yield:

: 327027-77-0
(Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

: (2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-1-[(2S,6R)-6-((Z)-4-hydroxy-but-2-enyl)-3,6-dihydro-2H-pyran-2-yl]-10-(4-methoxy-benzyloxy)-undeca-2,7-dien-4-one

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;
DOI:10.1021/ol000342+

Reference yield:

: 327027-77-0
(Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

: 327027-80-5
(3Z,9E,14E)-(1R,7S,11R,17S)-11-(tert-Butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxymethyl)-6,21-dioxa-bicyclo[15.3.1]henicosa-3,9,14,19-tetraene-5,13-dione

Guidance literature:: Multi-step reaction with 5 steps

1: DIBAL / CH₂Cl₂ / -78 °C

2: Dess-Martin periodinane

3: NaClO₂; NaH₂PO₄; Me₂C=CHMe / 2-methyl-propan-2-ol

4: 77 percent / DDQ / CH₂Cl₂ / pH 7

5: DEAD; PPh₃ / benzene / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diisobutylaluminium hydride; Dess-Martin periodane; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; diethylazodicarboxylate; In dichloromethane; tert-butyl alcohol; benzene; 5: Mitsunobu macrolactonization;
DOI:10.1021/ol000342+