butyl 2-(7-fluoro-4-(4-fluorophenyl)-2-tosyl-1,2-dihydrophthalazin-1-yl)acetate

Base Information

Chemical Name:butyl 2-(7-fluoro-4-(4-fluorophenyl)-2-tosyl-1,2-dihydrophthalazin-1-yl)acetate
CAS No.:1402416-20-9
Molecular Formula:C₂₇H₂₆F₂N₂O₄S
Molecular Weight:512.577
Hs Code.:

Synonyms:butyl 2-(7-fluoro-4-(4-fluorophenyl)-2-tosyl-1,2-dihydrophthalazin-1-yl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of butyl 2-(7-fluoro-4-(4-fluorophenyl)-2-tosyl-1,2-dihydrophthalazin-1-yl)acetate

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Technology Process of butyl 2-(7-fluoro-4-(4-fluorophenyl)-2-tosyl-1,2-dihydrophthalazin-1-yl)acetate

There total 2 articles about butyl 2-(7-fluoro-4-(4-fluorophenyl)-2-tosyl-1,2-dihydrophthalazin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 141-32-2,9003-49-0
acrylic acid n-butyl ester

: 1326704-82-8
N′-(bis(4-fluorophenyl)methylene)-4-methylbenzenesulfonohydrazide

: 1402416-20-9
butyl 2-(7-fluoro-4-(4-fluorophenyl)-2-tosyl-1,2-dihydrophthalazin-1-yl)acetate

Guidance literature:: With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate; In N,N-dimethyl-formamide; at 80 ℃; for 18h; Sealed tube; Inert atmosphere;
DOI:10.1021/ol302522n

Reference yield:

: 345-92-6
4,4'-Difluorobenzophenone

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 1402416-20-9
butyl 2-(7-fluoro-4-(4-fluorophenyl)-2-tosyl-1,2-dihydrophthalazin-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water; methanol / 2 h / Reflux

2: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate / N,N-dimethyl-formamide / 18 h / 80 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ol302522n