4-(3-chlorophenyl)-6-(6-fluoropyridin-3-ylmethyl)-2-methylbenzothiazole

Base Information

Chemical Name:4-(3-chlorophenyl)-6-(6-fluoropyridin-3-ylmethyl)-2-methylbenzothiazole
CAS No.:1155288-00-8
Molecular Formula:C₂₀H₁₄ClFN₂S
Molecular Weight:368.862
Hs Code.:

Synonyms:4-(3-chlorophenyl)-6-(6-fluoropyridin-3-ylmethyl)-2-methylbenzothiazole

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Chemical Property of 4-(3-chlorophenyl)-6-(6-fluoropyridin-3-ylmethyl)-2-methylbenzothiazole

Chemical Property:

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Technology Process of 4-(3-chlorophenyl)-6-(6-fluoropyridin-3-ylmethyl)-2-methylbenzothiazole

There total 1 articles about 4-(3-chlorophenyl)-6-(6-fluoropyridin-3-ylmethyl)-2-methylbenzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1155287-99-2
6-bromomethyl-4-(3-chloro-phenyl)-2-methyl-benzothiazole

: 351019-18-6
(6-fluoropyridin-3-yl)boronic acid

: 1155288-00-8
4-(3-chlorophenyl)-6-(6-fluoropyridin-3-ylmethyl)-2-methylbenzothiazole

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene;

Reference yield:

: 1155288-00-8
4-(3-chlorophenyl)-6-(6-fluoropyridin-3-ylmethyl)-2-methylbenzothiazole

: 2133-34-8,20063-89-2
(2S)-azetidine-2-carboxylic acid

: 1155287-03-8
(S)-1-{5-[4-(3-chlorophenyl)-2-methylbenzothiazol-6-ylmethyl]pyridin-2-yl}azetidine-2-carboxylic acid

Guidance literature:: 4-(3-chlorophenyl)-6-(6-fluoropyridin-3-ylmethyl)-2-methylbenzothiazole; (2S)-azetidine-2-carboxylic acid; With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 150 ℃; for 0.25h; Neat (no solvent);

With hydrogenchloride; In dichloromethane; water; at 20 ℃;

Reference yield:

: 1155288-00-8
4-(3-chlorophenyl)-6-(6-fluoropyridin-3-ylmethyl)-2-methylbenzothiazole

: 7729-30-8,20063-89-2
(R)-azetidine-2-carboxylic acid

: 1155287-05-0
(R)-1-{5-[4-(3-chlorophenyl)-2-methylbenzothiazol-6-ylmethyl]pyridin-2-yl}azetidine-2-carboxylic acid

Guidance literature:: 4-(3-chlorophenyl)-6-(6-fluoropyridin-3-ylmethyl)-2-methylbenzothiazole; (R)-azetidine-2-carboxylic acid; With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 150 ℃; for 0.25h; Neat (no solvent);

With hydrogenchloride; In dichloromethane; water; at 20 ℃;