N-methyl-N-benzyl-2-(3,4-dimethoxyphenyl)-2-hydroxyethylamine

Base Information

• Chemical Name: N-methyl-N-benzyl-2-(3,4-dimethoxyphenyl)-2-hydroxyethylamine
• CAS No.: 345231-54-1
• Molecular Formula: C₁₈H₂₃NO₃
• Molecular Weight: 301.386
• Mol file: 345231-54-1.mol

Synonyms:N-methyl-N-benzyl-2-(3,4-dimethoxyphenyl)-2-hydroxyethylamine

Chemical Property of N-methyl-N-benzyl-2-(3,4-dimethoxyphenyl)-2-hydroxyethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-methyl-N-benzyl-2-(3,4-dimethoxyphenyl)-2-hydroxyethylamine

There total 6 articles about N-methyl-N-benzyl-2-(3,4-dimethoxyphenyl)-2-hydroxyethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

α-(N-methyl-N-benzylamino)-3,4-dimethoxyacetophenone (33342-73-3) → N-methyl-N-benzyl-2-(3,4-dimethoxyphenyl)-2-hydroxyethylamine (345231-54-1,1329792-70-2)

Guidance literature:

With sodium tetrahydroborate; In ethanol; 1.) RT, overnight, 2.) reflux, 3 h;

DOI:10.1021/jm00140a021

Reference yield:

2-Bromo-1-(3,4-dimethoxyphenyl)ethanone (1835-02-5) → N-methyl-N-benzyl-2-(3,4-dimethoxyphenyl)-2-hydroxyethylamine (345231-54-1,1329792-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: 80 percent / NaBH₄ / ethanol / 1.) RT, overnight, 2.) reflux, 3 h

With sodium tetrahydroborate; In ethanol; benzene;

DOI:10.1021/jm00140a021

Reference yield:

benzyl-methyl-amine (103-67-3) → N-methyl-N-benzyl-2-(3,4-dimethoxyphenyl)-2-hydroxyethylamine (345231-54-1,1329792-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: 80 percent / NaBH₄ / ethanol / 1.) RT, overnight, 2.) reflux, 3 h

With sodium tetrahydroborate; In ethanol; benzene;

DOI:10.1021/jm00140a021

upstream raw materials:

α-(N-methyl-N-benzylamino)-3,4-dimethoxyacetophenone

2-Bromo-1-(3,4-dimethoxyphenyl)ethanone

benzyl-methyl-amine

1-(3,4-dimethoxyphenyl)ethanone

Downstream raw materials:

1-(3,4-dimethoxyphenyl)-2-(methylamino)ethan-1-ol

2-methyl-4-(3',4'-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

2-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide