diethyl <<6-(bromomethyl)-4-phenylpyridin-2-y>methyl>phosphonate

Base Information

• Chemical Name: diethyl <<6-(bromomethyl)-4-phenylpyridin-2-y>methyl>phosphonate
• CAS No.: 174575-47-4
• Molecular Formula: C₁₇H₂₁BrNO₃P
• Molecular Weight: 398.236
• Mol file: 174575-47-4.mol

Synonyms:diethyl <<6-(bromomethyl)-4-phenylpyridin-2-y>methyl>phosphonate

Chemical Property of diethyl <<6-(bromomethyl)-4-phenylpyridin-2-y>methyl>phosphonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of diethyl <<6-(bromomethyl)-4-phenylpyridin-2-y>methyl>phosphonate

There total 1 articles about diethyl <<6-(bromomethyl)-4-phenylpyridin-2-y>methyl>phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-phenyl-bis(2,6-bromomethyl)pyridine (117095-84-8) + triethyl phosphite (122-52-1) → diethyl <<6-(bromomethyl)-4-phenylpyridin-2-y>methyl>phosphonate (174575-47-4)

Guidance literature:

In xylene; Heating;

DOI:10.1002/hlca.19950780810

Reference yield: 76.0%

(2S)-1-(tert-butyloxycarbonyl)-2-tert-butyl-3-methylimidazolidin-4-one (119838-38-9) + diethyl <<6-(bromomethyl)-4-phenylpyridin-2-y>methyl>phosphonate (174575-47-4) → 1,1-dimethylethyl (2S,5S)-5-<<6-<(diethoxyphopsphoryl)methyl>-4-phenylpyridin-2-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate (174575-45-2)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -70 ℃;

DOI:10.1002/hlca.19950780810

Reference yield:

diethyl <<6-(bromomethyl)-4-phenylpyridin-2-y>methyl>phosphonate (174575-47-4) → (S)-α-amino-4-phenyl-6-(phosphonomethyl)pyridine-2-propanoic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / (i-Pr)2NH, 1.6M BuLi / tetrahydrofuran; hexane / -70 °C

2: acetonitrile / Ambient temperature

3: 1.) 0.375M aq. H₂SO₄; 2.) Dowex 50 W / xylene / 1.) 70 deg C; 2.) reflux

With n-butyllithium; Dowex 50 W; sulfuric acid; diisopropylamine; In tetrahydrofuran; hexane; acetonitrile; xylene;

DOI:10.1002/hlca.19950780810

upstream raw materials:

4-phenyl-bis(2,6-bromomethyl)pyridine

triethyl phosphite

Downstream raw materials:

1,1-dimethylethyl (2S,5S)-5-<<6-<(diethoxyphopsphoryl)methyl>-4-phenylpyridin-2-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

1,1-dimethylethyl (2S,5S)-2-(1,1-dimethylethyl)-3-methyl-4-oxo-5-<<4-phenyl-6-(phopsphonomethyl)pyridin-2-yl>methyl>imidazolidine-1-carboxylate 1'-oxide