4-((S)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide

Base Information

Chemical Name:4-((S)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide
CAS No.:406235-62-9
Molecular Formula:C₂₀H₂₄N₄O₆S₂
Molecular Weight:480.566
Hs Code.:

Synonyms:4-((S)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide

Suppliers and Price of 4-((S)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((S)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide

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Technology Process of 4-((S)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide

There total 6 articles about 4-((S)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 872866-37-0
(S)-3-(2-nitro-4-sulfamoylphenylamino)-4-phenylsulfanylbutyric acid

: 406235-62-9
4-((S)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm050754u

Reference yield:

: 406233-31-6
4-fluoro-3-nitrobenzenesulfonamide

: 406235-62-9
4-((S)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: DIPEA / dimethylformamide / 12 h / 20 °C

2: HCl / dioxane / 6 h / 20 °C

3: EDCI; DMAP / tetrahydrofuran; dimethylformamide / 16 h / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm050754u

Reference yield:

: 872866-36-9
(S)-3-(2-nitro-4-sulfamoylphenylamino)-4-phenylsulfanylbutyric acid tert-butyl ester

: 406235-62-9
4-((S)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / dioxane / 6 h / 20 °C

2: EDCI; DMAP / tetrahydrofuran; dimethylformamide / 16 h / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm050754u