methyl (2S,4S,6R)-N-tert-butoxycarbonyl-4-(N-tert-butoxycarbonylamidobenzyl)pyroglutamate

Base Information

Chemical Name:methyl (2S,4S,6R)-N-tert-butoxycarbonyl-4-(N-tert-butoxycarbonylamidobenzyl)pyroglutamate
CAS No.:1242161-26-7
Molecular Formula:C₂₃H₃₂N₂O₇
Molecular Weight:448.516
Hs Code.:

Synonyms:methyl (2S,4S,6R)-N-tert-butoxycarbonyl-4-(N-tert-butoxycarbonylamidobenzyl)pyroglutamate

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Chemical Property of methyl (2S,4S,6R)-N-tert-butoxycarbonyl-4-(N-tert-butoxycarbonylamidobenzyl)pyroglutamate

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Technology Process of methyl (2S,4S,6R)-N-tert-butoxycarbonyl-4-(N-tert-butoxycarbonylamidobenzyl)pyroglutamate

There total 2 articles about methyl (2S,4S,6R)-N-tert-butoxycarbonyl-4-(N-tert-butoxycarbonylamidobenzyl)pyroglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 108963-96-8
(S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one

: 150884-50-7
benzaldehyde N-boc imine

: 1242161-26-7
methyl (2S,4S,6R)-N-tert-butoxycarbonyl-4-(N-tert-butoxycarbonylamidobenzyl)pyroglutamate

Guidance literature:: (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one; With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 1.5h; Inert atmosphere;

benzaldehyde N-boc imine; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2010.05.102

Reference yield: 29.0%

: 108963-96-8
(S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one

: 150884-50-7
benzaldehyde N-boc imine

: 1242161-27-8
methyl (2S,4S,6S)-N-tert-butoxycarbonyl-4-(N-tert-butoxycarbonylamidobenzyl)pyroglutamate

: 1242161-26-7
methyl (2S,4S,6R)-N-tert-butoxycarbonyl-4-(N-tert-butoxycarbonylamidobenzyl)pyroglutamate

: 1242161-28-9
methyl (2S,4R,6R)-N-tert-butoxycarbonyl-4-(N-tert-butoxycarbonylamidobenzyl)pyroglutamate

Guidance literature:: (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

benzaldehyde N-boc imine; In tetrahydrofuran; at -78 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2010.05.102