tert-butyl [8-(2-amino-2-oxoethyl)-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl]carbamate

Base Information

Chemical Name:tert-butyl [8-(2-amino-2-oxoethyl)-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl]carbamate
CAS No.:1240833-00-4
Molecular Formula:C₂₃H₂₆N₆O₄S
Molecular Weight:482.563
Hs Code.:

Synonyms:tert-butyl [8-(2-amino-2-oxoethyl)-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl]carbamate

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Chemical Property of tert-butyl [8-(2-amino-2-oxoethyl)-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl]carbamate

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Technology Process of tert-butyl [8-(2-amino-2-oxoethyl)-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl]carbamate

There total 12 articles about tert-butyl [8-(2-amino-2-oxoethyl)-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1240832-70-5
ethyl {4-[bis(tert-butoxycarbonyl)amino]-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}acetate

: 1240833-00-4
tert-butyl [8-(2-amino-2-oxoethyl)-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl]carbamate

Guidance literature:: ethyl {4-[bis(tert-butoxycarbonyl)amino]-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}acetate; With sodium hydroxide; In ethanol; water; at 20 ℃;

With hydrogenchloride; In ethanol; water;

With ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; at 20 ℃; for 72h;

Reference yield:

: C₈H₁₁Cl₂N₃O₃

: 1240833-00-4
tert-butyl [8-(2-amino-2-oxoethyl)-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl]carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 14 h / 20 °C

2.1: acetic anhydride; dimethyl sulfoxide / 18 h / 20 °C

3.1: triethylamine / dichloromethane / 17.5 h / Cooling with ice

4.1: dmap / tetrahydrofuran / 12 h / 20 °C

5.1: copper(II) choride dihydrate / acetonitrile / 2 h / 20 °C

6.1: methanesulfonyl chloride; 2,4,6-trimethyl-pyridine / dichloromethane / 15 h / 4 °C

6.2: 1.5 h / 20 °C / Cooling with ice

6.3: 5 h / 50 °C

7.1: pyridine / dimethyl sulfoxide / 15.5 h / 20 °C / Inert atmosphere; Cooling one ice

8.1: potassium carbonate; methanol / 1.5 h / Cooling with ice

9.1: toluene / 13 h / 65 °C

10.1: sodium hydroxide / ethanol; water / 20 °C

10.3: 72 h / 20 °C

With pyridine; 2,4,6-trimethyl-pyridine; methanol; dmap; copper(II) choride dihydrate; acetic anhydride; potassium carbonate; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; sodium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 5604-46-6
2-amino-4,6-dichloropyrimidine-5-carboxaldehyde

: 1240833-00-4
tert-butyl [8-(2-amino-2-oxoethyl)-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl]carbamate

Guidance literature:: Multi-step reaction with 12 steps

1.1: sodium iodide; zinc; indium / N,N-dimethyl-formamide / 3 h

2.1: water; 4-methylmorpholine N-oxide / osmium(VIII) oxide / tetrahydrofuran; acetone / 48 h / 20 °C

3.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 14 h / 20 °C

4.1: acetic anhydride; dimethyl sulfoxide / 18 h / 20 °C

5.1: triethylamine / dichloromethane / 17.5 h / Cooling with ice

6.1: dmap / tetrahydrofuran / 12 h / 20 °C

7.1: copper(II) choride dihydrate / acetonitrile / 2 h / 20 °C

8.1: methanesulfonyl chloride; 2,4,6-trimethyl-pyridine / dichloromethane / 15 h / 4 °C

8.2: 1.5 h / 20 °C / Cooling with ice

8.3: 5 h / 50 °C

9.1: pyridine / dimethyl sulfoxide / 15.5 h / 20 °C / Inert atmosphere; Cooling one ice

10.1: potassium carbonate; methanol / 1.5 h / Cooling with ice

11.1: toluene / 13 h / 65 °C

12.1: sodium hydroxide / ethanol; water / 20 °C

12.3: 72 h / 20 °C

With pyridine; 2,4,6-trimethyl-pyridine; methanol; dmap; indium; copper(II) choride dihydrate; water; acetic anhydride; potassium carbonate; dimethyl sulfoxide; methanesulfonyl chloride; 4-methylmorpholine N-oxide; triethylamine; sodium iodide; sodium hydroxide; zinc; osmium(VIII) oxide; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;