N₁-[3,5-bis(trifluoromethyl)phenyl]-2-(9-isopropyl-9H-purin-6-yl)-N₃-[3-(methoxycarbonyl)phenyl]benzene-1,3-diamine

Base Information

• Chemical Name: N₁-[3,5-bis(trifluoromethyl)phenyl]-2-(9-isopropyl-9H-purin-6-yl)-N₃-[3-(methoxycarbonyl)phenyl]benzene-1,3-diamine
• CAS No.: 1535484-65-1
• Molecular Formula: C₃₀H₂₄F₆N₆O₂
• Molecular Weight: 614.55

Synonyms:N₁-[3,5-bis(trifluoromethyl)phenyl]-2-(9-isopropyl-9H-purin-6-yl)-N₃-[3-(methoxycarbonyl)phenyl]benzene-1,3-diamine

Chemical Property of N₁-[3,5-bis(trifluoromethyl)phenyl]-2-(9-isopropyl-9H-purin-6-yl)-N₃-[3-(methoxycarbonyl)phenyl]benzene-1,3-diamine

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Technology Process of N₁-[3,5-bis(trifluoromethyl)phenyl]-2-(9-isopropyl-9H-purin-6-yl)-N₃-[3-(methoxycarbonyl)phenyl]benzene-1,3-diamine

There total 3 articles about N₁-[3,5-bis(trifluoromethyl)phenyl]-2-(9-isopropyl-9H-purin-6-yl)-N₃-[3-(methoxycarbonyl)phenyl]benzene-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-[2-(9-isopropyl-9H-purin-6-yl)phenyl]-3,5-bis(trifluoromethyl)aniline (1535484-01-5) + methyl 3-azidobenzoate (93066-93-4) → N1-[3,5-bis(trifluoromethyl)phenyl]-2-(9-isopropyl-9H-purin-6-yl)-N3-[3-(methoxycarbonyl)phenyl]benzene-1,3-diamine (1535484-65-1)

Guidance literature:

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In 1,2-dichloro-ethane; at 85 ℃; for 12h;

DOI:10.1021/ja4118472

Reference yield:

3,5-bis(trifluoromethyl)phenyl azide → N1-[3,5-bis(trifluoromethyl)phenyl]-2-(9-isopropyl-9H-purin-6-yl)-N3-[3-(methoxycarbonyl)phenyl]benzene-1,3-diamine (1535484-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: C₂₄H₂₉ClN₄Rh; silver hexafluoroantimonate / 1,2-dichloro-ethane / 12 h / 85 °C

2: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate / 1,2-dichloro-ethane / 12 h / 85 °C

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; C₂₄H₂₉ClN₄Rh; In 1,2-dichloro-ethane;

DOI:10.1021/ja4118472

Reference yield:

9-isopropyl-6-phenyl-9H-purine (1310063-64-9) → N1-[3,5-bis(trifluoromethyl)phenyl]-2-(9-isopropyl-9H-purin-6-yl)-N3-[3-(methoxycarbonyl)phenyl]benzene-1,3-diamine (1535484-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: C₂₄H₂₉ClN₄Rh; silver hexafluoroantimonate / 1,2-dichloro-ethane / 12 h / 85 °C

2: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate / 1,2-dichloro-ethane / 12 h / 85 °C

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; C₂₄H₂₉ClN₄Rh; In 1,2-dichloro-ethane;

DOI:10.1021/ja4118472

upstream raw materials:

N-[2-(9-isopropyl-9H-purin-6-yl)phenyl]-3,5-bis(trifluoromethyl)aniline

methyl 3-azidobenzoate

9-isopropyl-6-phenyl-9H-purine

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