2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1-benzofuran-6-carboxylic acid

Base Information

Chemical Name:2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1-benzofuran-6-carboxylic acid
CAS No.:1299483-20-7
Molecular Formula:C₁₉H₁₁F₆NO₄
Molecular Weight:431.291
Hs Code.:

Synonyms:2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1-benzofuran-6-carboxylic acid

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Chemical Property of 2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1-benzofuran-6-carboxylic acid

Chemical Property:

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Technology Process of 2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1-benzofuran-6-carboxylic acid

There total 5 articles about 2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1-benzofuran-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65686-68-2,1213368-14-9,1213841-80-5
2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethanamine

: 1299483-18-3
6-(tert-butoxycarbonyl)-1-benzofuran-2-carboxylic acid

: 1299483-20-7
2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1-benzofuran-6-carboxylic acid

Guidance literature:: 2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethanamine; 6-(tert-butoxycarbonyl)-1-benzofuran-2-carboxylic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In N,N-dimethyl-formamide; at 50 ℃;

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 65686-68-2,1213368-14-9,1213841-80-5
2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethanamine

: 1299483-18-3
6-(tert-butoxycarbonyl)-1-benzofuran-2-carboxylic acid

: 1299483-20-7
2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1-benzofuran-6-carboxylic acid

: 1299483-19-4
tert-butyl 2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1-benzofuran-6-carboxylate

Guidance literature:: With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

: 619-12-5
4-formyl-3-hydroxybenzoic acid

: 1299483-20-7
2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1-benzofuran-6-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 1.5 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3.1: sodium hydroxide / ethanol / 2 h / Reflux

3.2: Cooling with ice

4.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 50 °C

With potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;