(2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-hydroxypyrrolidine

Base Information

Chemical Name:(2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-hydroxypyrrolidine
CAS No.:174541-89-0
Molecular Formula:C₁₇H₂₅NO₄
Molecular Weight:307.39
Hs Code.:

Synonyms:(2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-hydroxypyrrolidine

Suppliers and Price of (2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-hydroxypyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-hydroxypyrrolidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-hydroxypyrrolidine

There total 9 articles about (2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-hydroxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 174541-88-9
(2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-<(4-nitrobenzoyl)oxy>-pyrrolidine

: 174541-89-0
(2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-hydroxypyrrolidine

Guidance literature:: With sodium hydroxide; In methanol; Ambient temperature;
DOI:10.1016/0957-4166(95)00434-3

Reference yield:

: 153805-41-5
methyl (4R,5R)-4-(benzyloxy)methyl-2-oxo-5-oxazolidineacetate

: 174541-89-0
(2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / NaBH₄ / tetrahydrofuran; methanol / Ambient temperature

2: aq. Ba(OH)2 / ethanol / Heating

3: Et₃N / tetrahydrofuran / Ambient temperature

4: 67 percent / pyridine / 3 h / -10 °C

5: 86 percent / NaH / tetrahydrofuran / 3 h / 0 °C

6: 90 percent / Ph₃P, diethylazodicarboxylate / benzene / 6 h / Ambient temperature

7: 90 percent / NaOH / methanol / Ambient temperature

With pyridine; barium dihydroxide; sodium hydroxide; sodium tetrahydroborate; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; benzene;
DOI:10.1016/0957-4166(95)00434-3

Reference yield:

: 153805-45-9
(4R,5R)-4-(benzyloxy)methyl-5-(2-hydroxyethyl)-2-oxo-oxazolidine

: 174541-89-0
(2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1: aq. Ba(OH)2 / ethanol / Heating

2: Et₃N / tetrahydrofuran / Ambient temperature

3: 67 percent / pyridine / 3 h / -10 °C

4: 86 percent / NaH / tetrahydrofuran / 3 h / 0 °C

5: 90 percent / Ph₃P, diethylazodicarboxylate / benzene / 6 h / Ambient temperature

6: 90 percent / NaOH / methanol / Ambient temperature

With pyridine; barium dihydroxide; sodium hydroxide; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; benzene;
DOI:10.1016/0957-4166(95)00434-3