N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)propyloxycarbonyl]-3-dephenyl-3'-(4-fluorophenyl)docetaxel

Base Information

Chemical Name:N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)propyloxycarbonyl]-3-dephenyl-3'-(4-fluorophenyl)docetaxel
CAS No.:1300036-15-0
Molecular Formula:C₄₃H₄₉F₄NO₁₄
Molecular Weight:879.854
Hs Code.:

Synonyms:N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)propyloxycarbonyl]-3-dephenyl-3'-(4-fluorophenyl)docetaxel

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Chemical Property of N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)propyloxycarbonyl]-3-dephenyl-3'-(4-fluorophenyl)docetaxel

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Technology Process of N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)propyloxycarbonyl]-3-dephenyl-3'-(4-fluorophenyl)docetaxel

There total 15 articles about N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)propyloxycarbonyl]-3-dephenyl-3'-(4-fluorophenyl)docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.5%

: 1300036-13-8
N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel

: 1300036-15-0
N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)propyloxycarbonyl]-3-dephenyl-3'-(4-fluorophenyl)docetaxel

Guidance literature:: With acetic acid; zinc; In methanol; at 50 ℃; for 1h;
DOI:10.1016/j.ejmech.2011.02.027

Reference yield:

: 1300036-09-2
isopropyl (2R,3S)-3-acetylamino-2-hydroxy-3-(4-fluorophenyl)propionate

: 1300036-15-0
N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)propyloxycarbonyl]-3-dephenyl-3'-(4-fluorophenyl)docetaxel

Guidance literature:: Multi-step reaction with 9 steps

1: hydrogenchloride; water / 4 h / Reflux

2: thionyl chloride / 0 - 20 °C

3: triethylamine / dichloromethane / 48 h / 0 - 20 °C

4: pyridinium p-toluenesulfonate / toluene / 3 h / 90 °C

5: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C

6: dmap; dicyclohexyl-carbodiimide / toluene

7: formic acid / 2 h / 20 °C

8: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C

9: acetic acid; zinc / methanol / 1 h / 50 °C

With hydrogenchloride; dmap; formic acid; thionyl chloride; water; pyridinium p-toluenesulfonate; acetic acid; triethylamine; dicyclohexyl-carbodiimide; lithium hydroxide; zinc; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1016/j.ejmech.2011.02.027

Reference yield:

: 459-32-5
(E)-4-fluorocinnamic acid

: 1300036-15-0
N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)propyloxycarbonyl]-3-dephenyl-3'-(4-fluorophenyl)docetaxel

Guidance literature:: Multi-step reaction with 11 steps

1: thionyl chloride / 4 h / 0 - 85 °C / Inert atmosphere

2: potassium osmate(VI) dihydrate; lithium hydroxide monohydrate; hydroquinidein 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 10 h / 0 °C

3: hydrogenchloride; water / 4 h / Reflux

4: thionyl chloride / 0 - 20 °C

5: triethylamine / dichloromethane / 48 h / 0 - 20 °C

6: pyridinium p-toluenesulfonate / toluene / 3 h / 90 °C

7: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C

8: dmap; dicyclohexyl-carbodiimide / toluene

9: formic acid / 2 h / 20 °C

10: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C

11: acetic acid; zinc / methanol / 1 h / 50 °C

With hydrogenchloride; dmap; potassium osmate(VI) dihydrate; formic acid; thionyl chloride; lithium hydroxide monohydrate; water; pyridinium p-toluenesulfonate; acetic acid; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; dicyclohexyl-carbodiimide; lithium hydroxide; zinc; In tetrahydrofuran; methanol; dichloromethane; water; toluene; tert-butyl alcohol; 2: Sharpless aminohydroxylation;
DOI:10.1016/j.ejmech.2011.02.027