5-Cyclopropyl-1,3,4-oxadiazol-2-amine

Base Information

• Chemical Name: 5-Cyclopropyl-1,3,4-oxadiazol-2-amine
• CAS No.: 89179-60-2
• Molecular Formula: C₅H₇N₃O
• Molecular Weight: 125.13
• Hs Code.: 2934999090
• European Community (EC) Number: 857-651-6
• DSSTox Substance ID: DTXSID00588015
• Wikidata: Q72461045
• Mol file: 89179-60-2.mol

Synonyms:5-cyclopropyl-1,3,4-oxadiazol-2-amine;89179-60-2;MFCD09041179;2-Amino-5-cyclopropyl-1,3,4-oxadiazol;5-Cyclopropyl-[1,3,4]oxadiazol-2-ylamine;SCHEMBL1924555;DTXSID00588015;BXHGGEZILMHEAM-UHFFFAOYSA-N;AKOS000123461;CS-W011175;MCULE-9311276181;PB34357;2-Amino-5-cyclopropyl-1,3,4-oxadiazole;BS-13007;DA-18455;SY083051;5-cyclopropyl[1,3,4]oxadiazol-2-ylamine;EN300-29742;P10685;A861288;5-Cyclopropyl-1,3,4-oxadiazol-2-amine, AldrichCPR;F2182-0120;Z235362809

Chemical Property of 5-Cyclopropyl-1,3,4-oxadiazol-2-amine

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.614
• Boiling Point: 282℃
• PKA: -0.58±0.13(Predicted)
• Flash Point: 124℃
• PSA: 64.94000
• Density: 1.406
• LogP: 1.11040
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 125.058911855
• Heavy Atom Count: 9
• Complexity: 115

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-5-cyclopropyl-1,3,4-oxadiazol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1C2=NN=C(O2)N
• Uses: 5-Cyclopropyl-1,3,4-oxadiazol-2-amine has been demonstated to lower in blood sugar of mammals such as rats and dogs.

Technology Process of 5-Cyclopropyl-1,3,4-oxadiazol-2-amine

There total 2 articles about 5-Cyclopropyl-1,3,4-oxadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

cyclopropanecarbohydrazide (6952-93-8) + bromocyane (506-68-3) → 5-cyclopropyl-1,3,4-oxadiazol-2-amine (89179-60-2)

Guidance literature:

In ethanol; at 60 ℃; for 2h;

Reference yield: 37.0%

→ 5-cyclopropyl-1,3,4-oxadiazol-2-amine (89179-60-2)

Guidance literature:

In ethanol; at 20 ℃; for 6h;

Reference yield: 62.0%

6,7-dimethoxy-2-phenyl-4H-benzo[d][1,3]oxazin-4-one (31164-96-2) + 5-cyclopropyl-1,3,4-oxadiazol-2-amine (89179-60-2) → 3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-6,7-dimethoxy-2-phenylquinazolin-4-(3H)-one

Guidance literature:

With pyridine; for 24h; Reflux;

DOI:10.1039/c5ra05277g

upstream raw materials:

cyclopropanecarbohydrazide

bromocyane

Downstream raw materials:

N-(5-cyclopropyl-[1,3,4]oxadiazol-2-yl)-toluene-4-sulfonamide

Refernces