(S)-methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Base Information

Chemical Name:(S)-methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
CAS No.:1313581-97-3
Molecular Formula:C₂₇H₂₆FN₃O₃S
Molecular Weight:491.586
Hs Code.:

Synonyms:(S)-methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

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Chemical Property of (S)-methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

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Technology Process of (S)-methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

There total 8 articles about (S)-methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313579-17-7
(S)-methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

: 38985-64-7
o-fluorophenyl isothiocyanate

: 1313581-97-3
(S)-methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Guidance literature:: In tetrahydrofuran; at 20 ℃;

Reference yield:

: 118-90-1
ortho-methylbenzoic acid

: 1313581-97-3
(S)-methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine; iron / 16 h / 0 - 20 °C

2.1: thionyl chloride / 0 - 20 °C

3.1: potassium acetate; bis(pinacol)diborane / palladium diacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

3.2: 16 h / 80 °C / Inert atmosphere

4.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C

5.1: triethylamine / toluene / Reflux

6.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 16 h / Reflux

7.1: tetrahydrofuran / 20 °C

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); bromine; potassium acetate; iron; ammonium chloride; triethylamine; bis(pinacol)diborane; palladium diacetate; In tetrahydrofuran; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 79669-49-1
5-bromo-2-methylbenzoic acid

: 1313581-97-3
(S)-methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 0 - 20 °C

2.1: potassium acetate; bis(pinacol)diborane / palladium diacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

2.2: 16 h / 80 °C / Inert atmosphere

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C

4.1: triethylamine / toluene / Reflux

5.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 16 h / Reflux

6.1: tetrahydrofuran / 20 °C

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); potassium acetate; iron; ammonium chloride; triethylamine; bis(pinacol)diborane; palladium diacetate; In tetrahydrofuran; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; toluene;