(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-[2-(cyclopropyloxy)ethoxy]phenyl)-N-(pentylsulfonyl)acrylamide

Base Information

Chemical Name:(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-[2-(cyclopropyloxy)ethoxy]phenyl)-N-(pentylsulfonyl)acrylamide
CAS No.:926302-99-0
Molecular Formula:C₂₅H₂₈ClF₃N₂O₆S
Molecular Weight:577.021
Hs Code.:

Synonyms:(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-[2-(cyclopropyloxy)ethoxy]phenyl)-N-(pentylsulfonyl)acrylamide

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Chemical Property of (2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-[2-(cyclopropyloxy)ethoxy]phenyl)-N-(pentylsulfonyl)acrylamide

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Technology Process of (2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-[2-(cyclopropyloxy)ethoxy]phenyl)-N-(pentylsulfonyl)acrylamide

There total 5 articles about (2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-[2-(cyclopropyloxy)ethoxy]phenyl)-N-(pentylsulfonyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: (2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-[2-(cyclopropyloxy)ethoxy]phenyl)acrylic acid

: 52960-14-2
1-pentylsulfonamide

: 926302-99-0
(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-[2-(cyclopropyloxy)ethoxy]phenyl)-N-(pentylsulfonyl)acrylamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 926295-27-4
ethyl (2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-hydroxyphenyl)acrylate

: 926302-99-0
(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-[2-(cyclopropyloxy)ethoxy]phenyl)-N-(pentylsulfonyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

2.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

2.2: 20 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

With dmap; tributylphosphine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; water; acetonitrile; 1.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 926295-26-3
2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(methoxymethoxy)benzaldehyde

: 926302-99-0
(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-[2-(cyclopropyloxy)ethoxy]phenyl)-N-(pentylsulfonyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 0.5 h / 0 - 20 °C

2.1: hydrogenchloride; water / acetone / 5 h / Reflux

3.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

4.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

4.2: 20 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

With hydrogenchloride; dmap; tributylphosphine; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; water; acetone; acetonitrile; mineral oil; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination / 3.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.03.036