4-Methyl-N-{3-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-4-yl}-benzamide

Base Information

Chemical Name:4-Methyl-N-{3-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-4-yl}-benzamide
CAS No.:86162-95-0
Molecular Formula:C₂₃H₁₇N₃O₄
Molecular Weight:399.406
Hs Code.:

Synonyms:4-Methyl-N-{3-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-4-yl}-benzamide

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Chemical Property of 4-Methyl-N-{3-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-4-yl}-benzamide

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Technology Process of 4-Methyl-N-{3-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-4-yl}-benzamide

There total 6 articles about 4-Methyl-N-{3-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-4-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 555-16-8
4-nitrobenzaldehdye

: 86162-94-9
4-toluamidooxindole

: 86162-95-0
4-Methyl-N-{3-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-4-yl}-benzamide

Guidance literature:: With piperidine; In ethanol; for 24h; Heating;
DOI:10.1021/jo00163a006

Reference yield:

: 86162-89-2
dimethyl (2,6-dinitrophenyl)malonate

: 86162-95-0
4-Methyl-N-{3-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / 70percent perchloric acid / acetic acid / 1 h / Heating

2: 94 percent / 10percent palladium on carbon, H₂ / methanol / 2.) reflux, 72 h

3: 88 percent / pyridine; dioxane / 24 h / Ambient temperature

4: 93 percent / piperidine / ethanol / 24 h / Heating

With piperidine; palladium on activated charcoal; perchloric acid; hydrogen; In 1,4-dioxane; pyridine; methanol; ethanol; acetic acid;
DOI:10.1021/jo00163a006

Reference yield:

: 606-21-3
1-chloro-2,6-dinitrobenzene

: 86162-95-0
4-Methyl-N-{3-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) potassium tert-butoxide / 1.)DMF, 2.) 20 to 90 deg C, 2 h, 25 deg C, 16 h, to 10 deg C

2: 70 percent / 70percent perchloric acid / acetic acid / 1 h / Heating

3: 94 percent / 10percent palladium on carbon, H₂ / methanol / 2.) reflux, 72 h

4: 88 percent / pyridine; dioxane / 24 h / Ambient temperature

5: 93 percent / piperidine / ethanol / 24 h / Heating

With piperidine; palladium on activated charcoal; perchloric acid; potassium tert-butylate; hydrogen; In 1,4-dioxane; pyridine; methanol; ethanol; acetic acid;
DOI:10.1021/jo00163a006