C₂₈H₂₂ClFN₆O₃

Base Information

• Chemical Name: C₂₈H₂₂ClFN₆O₃
• CAS No.: 1373944-81-0
• Molecular Formula: C₂₈H₂₂ClFN₆O₃
• Molecular Weight: 544.972
• Mol file: 1373944-81-0.mol

Synonyms:C₂₈H₂₂ClFN₆O₃

Chemical Property of C₂₈H₂₂ClFN₆O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₂ClFN₆O₃

There total 4 articles about C₂₈H₂₂ClFN₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H12Cl2FN3O3 + 5-(aminomethyl)-2,2′-bipyridine (220339-96-8) → C28H22ClFN6O3 (1373944-81-0)

Guidance literature:

With triethylamine; In dichloromethane; at 5 ℃; for 3h; Cooling with ice;

Reference yield:

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline (184475-71-6) → C28H22ClFN6O3 (1373944-81-0)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 40 °C

2: sodium hydroxide / methanol; water; tetrahydrofuran / 12 h / 20 °C

3: pyridine; thionyl chloride / N,N-dimethyl-formamide / 70 - 75 °C

4: triethylamine / dichloromethane / 3 h / 5 °C / Cooling with ice

With pyridine; thionyl chloride; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

thyl 2-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)acetate (1012057-13-4) → C28H22ClFN6O3 (1373944-81-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol; water; tetrahydrofuran / 12 h / 20 °C

2: pyridine; thionyl chloride / N,N-dimethyl-formamide / 70 - 75 °C

3: triethylamine / dichloromethane / 3 h / 5 °C / Cooling with ice

With pyridine; thionyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

thyl 2-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)acetate

2-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)acetic acid

5-(aminomethyl)-2,2′-bipyridine

Downstream raw materials:

C₂₈H₂₄ClFN₆O₂