tert-butyl 3-[2-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]acetylamino]propionate

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Chemical Name:tert-butyl 3-[2-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]acetylamino]propionate
CAS No.:171051-14-2
Molecular Formula:C₃₂H₃₅N₅O₄
Molecular Weight:553.661
Hs Code.:

Synonyms:tert-butyl 3-[2-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]acetylamino]propionate

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Chemical Property of tert-butyl 3-[2-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]acetylamino]propionate

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Technology Process of tert-butyl 3-[2-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]acetylamino]propionate

There total 3 articles about tert-butyl 3-[2-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]acetylamino]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58620-93-2
tert-butyl 3-aminopropanoate hydrochloride

: {2-[6-oxo-3-(2-phenyl-pyrazolo[1,5-a]pyridin-3-yl)-6H-pyridazin-1-yl]-cyclohex-1-enyl}-acetyl chloride

: 171051-14-2
tert-butyl 3-[2-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]acetylamino]propionate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 5.5h;
DOI:10.1016/S0968-0896(99)00258-8

Reference yield:

: 171050-45-6
3-[2-(2-Carboxymethyl-1-cyclohexenyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]-pyridine

: 171051-14-2
tert-butyl 3-[2-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]acetylamino]propionate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂ / 2.5 h / 20 °C

2: Et₃N / CH₂Cl₂ / 5.5 h / 20 °C

With thionyl chloride; triethylamine; In dichloromethane; 1: Substitution / 2: amidation;
DOI:10.1016/S0968-0896(99)00258-8