4-(CARBOXY-NAPHTHALEN-1-YL-METHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: 4-(CARBOXY-NAPHTHALEN-1-YL-METHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE
• CAS No.: 885274-72-6
• Molecular Formula: C₂₁H₂₆N₂O₄
• Molecular Weight: 370.448
• Mol file: 885274-72-6.mol

Synonyms:4-(CARBOXY-NAPHTHALEN-1-YL-METHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

Chemical Property of 4-(CARBOXY-NAPHTHALEN-1-YL-METHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

Chemical Property:

• PSA: 70.08000
• LogP: 3.39400

Purity/Quality:

HPLC>98% ^*data from raw suppliers

4-(CARBOXY-NAPHTHALEN-1-YL-METHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(CARBOXY-NAPHTHALEN-1-YL-METHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

There total 2 articles about 4-(CARBOXY-NAPHTHALEN-1-YL-METHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

C22H28N2O4 → 2-(4-tert-butoxycarbonylpiperazin-1-yl)-2-(1-naphthyl)acetic acid (885274-72-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

Reference yield:

methyl 1-naphthylacetate (2876-78-0) → 2-(4-tert-butoxycarbonylpiperazin-1-yl)-2-(1-naphthyl)acetic acid (885274-72-6)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

With N-Bromosuccinimide; water; potassium carbonate; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

upstream raw materials:

methyl 1-naphthylacetate

Refernces