N-(6'-bromo-2'-pyridyl)-N'-(6''-benzylamino-2''-pyridyl)-2,6-diaminopyridine

Base Information

Chemical Name:N-(6'-bromo-2'-pyridyl)-N'-(6''-benzylamino-2''-pyridyl)-2,6-diaminopyridine
CAS No.:427900-22-9
Molecular Formula:C₂₂H₁₉BrN₆
Molecular Weight:447.337
Hs Code.:

Synonyms:N-(6'-bromo-2'-pyridyl)-N'-(6''-benzylamino-2''-pyridyl)-2,6-diaminopyridine

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Chemical Property of N-(6'-bromo-2'-pyridyl)-N'-(6''-benzylamino-2''-pyridyl)-2,6-diaminopyridine

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Technology Process of N-(6'-bromo-2'-pyridyl)-N'-(6''-benzylamino-2''-pyridyl)-2,6-diaminopyridine

There total 3 articles about N-(6'-bromo-2'-pyridyl)-N'-(6''-benzylamino-2''-pyridyl)-2,6-diaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 427900-17-2
2-N-benzylamino-6-bromopyridine

: 427900-26-3
N²-(6-bromopyridine-2-yl)pyridine-2,6-diamine

: 427900-22-9
N-(6'-bromo-2'-pyridyl)-N'-(6''-benzylamino-2''-pyridyl)-2,6-diaminopyridine

Guidance literature:: With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 18-crown-6 ether; In benzene; at 80 ℃; for 4h;
DOI:10.1021/ja011679p

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 427900-22-9
N-(6'-bromo-2'-pyridyl)-N'-(6''-benzylamino-2''-pyridyl)-2,6-diaminopyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / KO-tBu / benzene / 16 h / 80 °C

2: 38 percent / KO-tBu; Pd₂(dba)3; BINAP / 18-c-6 / benzene / 4 h / 80 °C

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 18-crown-6 ether; In benzene; 2: Buchwald's coupling;
DOI:10.1021/ja011679p

Reference yield:

: 100-46-9
benzylamine

: 427900-22-9
N-(6'-bromo-2'-pyridyl)-N'-(6''-benzylamino-2''-pyridyl)-2,6-diaminopyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 22 percent / Pd₂(dba)3; BINAP; KO-tBu / benzene / 4 h / 80 °C

2: 38 percent / KO-tBu; Pd₂(dba)3; BINAP / 18-c-6 / benzene / 4 h / 80 °C

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 18-crown-6 ether; In benzene; 1: Buchwald's coupling / 2: Buchwald's coupling;
DOI:10.1021/ja011679p