Technology Process of 2-{4-[(3-bromobenzyl)oxy]benzyl}-1,2,4-oxadiazolidine-3,5-dione
There total 1 articles about 2-{4-[(3-bromobenzyl)oxy]benzyl}-1,2,4-oxadiazolidine-3,5-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-((3-bromobenzyl)oxy)benzaldehyde;
With
hydroxylamine hydrochloride; sodium acetate;
In
ethanol; water;
at 20 ℃;
for 18h;
With
methanol; sodium cyanoborohydride;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
chlorocarbonyl isocyanate;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
cooling on an ice-methanol bath;
- Guidance literature:
-
(2,6-difluoro-4-methoxyphenyl)boronic acid; 2-{4-[(3-bromobenzyl)oxy]benzyl}-1,2,4-oxadiazolidine-3,5-dione;
With
sodium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; ethanol; water;
at 90 ℃;
for 25h;
With
sodium hydroxide;
In
tetrahydrofuran; ethanol; water;
