[3-[[2-[(3,5-dimorpholin-4-ylphenyl)amino]pyrimidin-4-yl]-methyl-amino]-4-methyl-phenyl]methanol besylate

Base Information

Chemical Name:[3-[[2-[(3,5-dimorpholin-4-ylphenyl)amino]pyrimidin-4-yl]-methyl-amino]-4-methyl-phenyl]methanol besylate
CAS No.:1051896-51-5
Molecular Formula:C₆H₆O₃S*C₂₇H₃₄N₆O₃
Molecular Weight:648.783
Hs Code.:

Synonyms:[3-[[2-[(3,5-dimorpholin-4-ylphenyl)amino]pyrimidin-4-yl]-methyl-amino]-4-methyl-phenyl]methanol besylate

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Chemical Property of [3-[[2-[(3,5-dimorpholin-4-ylphenyl)amino]pyrimidin-4-yl]-methyl-amino]-4-methyl-phenyl]methanol besylate

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Technology Process of [3-[[2-[(3,5-dimorpholin-4-ylphenyl)amino]pyrimidin-4-yl]-methyl-amino]-4-methyl-phenyl]methanol besylate

There total 7 articles about [3-[[2-[(3,5-dimorpholin-4-ylphenyl)amino]pyrimidin-4-yl]-methyl-amino]-4-methyl-phenyl]methanol besylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.2%

: 1051896-49-1
[3-[[2-[(3,5-dimorpholin-4-ylphenyl)amino]pyrimidin-4-yl]-methyl-amino]-4-methyl-phenyl]methanol

: 98-11-3
benzenesulfonic acid

: 1051896-51-5
[3-[[2-[(3,5-dimorpholin-4-ylphenyl)amino]pyrimidin-4-yl]-methyl-amino]-4-methyl-phenyl]methanol besylate

Guidance literature:: In acetonitrile; Heating / reflux;

Reference yield:

: 2265-94-3
1,3-difluoro-5-nitrobenzene

: 1051896-51-5
[3-[[2-[(3,5-dimorpholin-4-ylphenyl)amino]pyrimidin-4-yl]-methyl-amino]-4-methyl-phenyl]methanol besylate

Guidance literature:: Multi-step reaction with 4 steps

1: dimethyl sulfoxide / 90 h / 160 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 17 h / 20 °C / 760.05 Torr

3: isopropyl alcohol / 0.25 h / 140 °C

4: acetonitrile / 1 h

With hydrogen; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide; isopropyl alcohol; acetonitrile;

Reference yield:

: 220954-17-6
4,4’-(5-nitro-1,3-phenylene)dimorpholine

: 1051896-51-5
[3-[[2-[(3,5-dimorpholin-4-ylphenyl)amino]pyrimidin-4-yl]-methyl-amino]-4-methyl-phenyl]methanol besylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 17 h / 20 °C / 760.05 Torr

2: isopropyl alcohol / 0.25 h / 140 °C

3: acetonitrile / 1 h

With hydrogen; palladium 10% on activated carbon; In ethanol; isopropyl alcohol; acetonitrile;