N-methyl-7-[(4-methylphenyl)sulfonyl]-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Base Information

Chemical Name:N-methyl-7-[(4-methylphenyl)sulfonyl]-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS No.:1325182-06-6
Molecular Formula:C₂₀H₂₅N₅O₂S
Molecular Weight:399.517
Hs Code.:

Synonyms:N-methyl-7-[(4-methylphenyl)sulfonyl]-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methyl-7-[(4-methylphenyl)sulfonyl]-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-methyl-7-[(4-methylphenyl)sulfonyl]-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

There total 4 articles about N-methyl-7-[(4-methylphenyl)sulfonyl]-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

: 910789-32-1
methyl-[7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine

: C₆H₁₂ClN

: 1325182-06-6
N-methyl-7-[(4-methylphenyl)sulfonyl]-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; potassium tert-butylate; lead(II) chloride; In 1,4-dioxane; at 20 ℃; for 5h; Reagent/catalyst; Solvent; Inert atmosphere;

Reference yield:

: 72093-04-0
3-chloro-4-methylpyridine

: 1325182-06-6
N-methyl-7-[(4-methylphenyl)sulfonyl]-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium iodide; hydrogen / dichloromethane / 12 h / 20 °C / 10343.2 Torr / Autoclave

2: monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; potassium tert-butylate; lead(II) chloride / 1,4-dioxane / 5 h / 20 °C / Inert atmosphere

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; potassium tert-butylate; hydrogen; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium iodide; lead(II) chloride; In 1,4-dioxane; dichloromethane;

Reference yield:

: 78727-16-9
4-(methylamino)-7H-pyrrolo<2,3-d>pyrimidine

: 1325182-06-6
N-methyl-7-[(4-methylphenyl)sulfonyl]-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / acetonitrile / 30 - 50 °C

2: monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; potassium tert-butylate; lead(II) chloride / 1,4-dioxane / 5 h / 20 °C / Inert atmosphere

With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; potassium tert-butylate; sodium hydroxide; lead(II) chloride; In 1,4-dioxane; acetonitrile;