2-(1-benzenesulfonyl-3-{2-[3-(2-diazo-2-ethoxycarbonylacetyl)-3-ethyl-2-oxopiperidin-1-yl]-2-oxoethyl}-1H-indol-2-yl)acrylic acid methyl ester

Base Information

Chemical Name:2-(1-benzenesulfonyl-3-{2-[3-(2-diazo-2-ethoxycarbonylacetyl)-3-ethyl-2-oxopiperidin-1-yl]-2-oxoethyl}-1H-indol-2-yl)acrylic acid methyl ester
CAS No.:849738-63-2
Molecular Formula:C₃₂H₃₂N₄O₉S
Molecular Weight:648.693
Hs Code.:

Synonyms:2-(1-benzenesulfonyl-3-{2-[3-(2-diazo-2-ethoxycarbonylacetyl)-3-ethyl-2-oxopiperidin-1-yl]-2-oxoethyl}-1H-indol-2-yl)acrylic acid methyl ester

Suppliers and Price of 2-(1-benzenesulfonyl-3-{2-[3-(2-diazo-2-ethoxycarbonylacetyl)-3-ethyl-2-oxopiperidin-1-yl]-2-oxoethyl}-1H-indol-2-yl)acrylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(1-benzenesulfonyl-3-{2-[3-(2-diazo-2-ethoxycarbonylacetyl)-3-ethyl-2-oxopiperidin-1-yl]-2-oxoethyl}-1H-indol-2-yl)acrylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(1-benzenesulfonyl-3-{2-[3-(2-diazo-2-ethoxycarbonylacetyl)-3-ethyl-2-oxopiperidin-1-yl]-2-oxoethyl}-1H-indol-2-yl)acrylic acid methyl ester

There total 8 articles about 2-(1-benzenesulfonyl-3-{2-[3-(2-diazo-2-ethoxycarbonylacetyl)-3-ethyl-2-oxopiperidin-1-yl]-2-oxoethyl}-1H-indol-2-yl)acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 786704-01-6
2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester

: 849738-67-6
2-[1-benzenesulfonyl-3-(2-hydroxyethyl)-1H-indol-2-yl]acrylic acid methyl ester

: 849738-63-2
2-(1-benzenesulfonyl-3-{2-[3-(2-diazo-2-ethoxycarbonylacetyl)-3-ethyl-2-oxopiperidin-1-yl]-2-oxoethyl}-1H-indol-2-yl)acrylic acid methyl ester

Guidance literature:: 2-[1-benzenesulfonyl-3-(2-hydroxyethyl)-1H-indol-2-yl]acrylic acid methyl ester; With jones' reagent; In acetone; at 20 ℃; for 2h;

With phosphorus pentachloride; In diethyl ether; at 20 ℃; for 2h;

2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester; In tetrahydrofuran; for 20h;
DOI:10.1021/jo047834a

Reference yield:

: 140920-82-7
1-(O-tert-butyldimethylsilyl)-2-<3-(1-phenylsulfonyl)indolyl>ethanol

: 849738-63-2
2-(1-benzenesulfonyl-3-{2-[3-(2-diazo-2-ethoxycarbonylacetyl)-3-ethyl-2-oxopiperidin-1-yl]-2-oxoethyl}-1H-indol-2-yl)acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

1.2: 63 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.1: BF₃*OEt₂ / CH₂Cl₂ / 2 h / 20 °C

3.1: Et₃N; DMAP / CH₂Cl₂ / 0.17 h / 0 °C

4.1: p-TsOH*H₂O / benzene / 1 h / Heating

5.1: 1.4 g / Na₂CO₃ / methanol; H₂O / 0.5 h / Heating

6.1: Jones' reagent / acetone / 2 h / 20 °C

6.2: PCl₅ / diethyl ether / 2 h / 20 °C

6.3: 62 percent / tetrahydrofuran / 20 h

With dmap; n-butyllithium; jones' reagent; boron trifluoride diethyl etherate; sodium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetone; benzene; 6.1: Jones' oxidation;
DOI:10.1021/jo047834a

Reference yield:

: 168779-59-7
3-ethyl-2-oxo-piperidine-3-carboxylic acid

: 849738-63-2
2-(1-benzenesulfonyl-3-{2-[3-(2-diazo-2-ethoxycarbonylacetyl)-3-ethyl-2-oxopiperidin-1-yl]-2-oxoethyl}-1H-indol-2-yl)acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 12 h / 20 °C

1.2: 61 percent / isopropylmagnesium chloride / CH₂Cl₂; tetrahydrofuran / 12 h / 20 °C

2.1: 76 percent / Et₃N; mesyl azide / acetonitrile / 10 h / 25 °C

3.1: Jones' reagent / acetone / 2 h / 20 °C

3.2: PCl₅ / diethyl ether / 2 h / 20 °C

3.3: 62 percent / tetrahydrofuran / 20 h

With jones' reagent; triethylamine; Methanesulfonyl azide; 1,1'-carbonyldiimidazole; In dichloromethane; acetone; acetonitrile; 3.1: Jones' oxidation;
DOI:10.1021/jo047834a