rac-1-{4-amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}ethanol

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Chemical Name:rac-1-{4-amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}ethanol
CAS No.:1417736-42-5
Molecular Formula:C₁₅H₁₄F₂N₄O₂
Molecular Weight:320.299
Hs Code.:

Synonyms:rac-1-{4-amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}ethanol

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Chemical Property of rac-1-{4-amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}ethanol

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Technology Process of rac-1-{4-amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}ethanol

There total 5 articles about rac-1-{4-amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.6%

: 1417736-43-6
[2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol

: 1417736-98-1
rac-1-(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)ethanol

: 1417736-42-5
rac-1-{4-amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}ethanol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 140 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1369350-92-4
4-amino-5-bromopyrrolo [2,1-f][1,2,4]triazine-7-carbaldehyde

: 1417736-42-5
rac-1-{4-amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 1 h / 140 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water;

Reference yield:

: 939967-94-9
4-aminopyrrolo[2,1-f][1,2,4]triazine-7-carbaldehyde

: 1417736-42-5
rac-1-{4-amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 1 h / 140 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide;