N¹,N⁴-bis[(L)-threonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine dihydrobromide

Base Information

• Chemical Name: N¹,N⁴-bis[(L)-threonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine dihydrobromide
• CAS No.: 96857-12-4
• Molecular Formula: 2BrH*C₂₁H₃₅N₅O₇
• Molecular Weight: 631.362
• Mol file: 96857-12-4.mol

Synonyms:N¹,N⁴-bis[(L)-threonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine dihydrobromide

Chemical Property of N¹,N⁴-bis[(L)-threonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine dihydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹,N⁴-bis[(L)-threonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine dihydrobromide

There total 9 articles about N¹,N⁴-bis[(L)-threonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine dihydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N1,N4-bis((L)-threonyl)-N7-(2,3-dimethoxybenzoyl)norspermidine (96857-11-3) → N1,N4-bis[(L)-threonyl]-N7-(2,3-dimethoxybenzoyl)norspermidine dihydrobromide (96857-12-4)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 22h;

DOI:10.1016/S0040-4020(01)96492-0

Reference yield: 90.0%

N1,N4-bis[(L)-N-tert-butoxycarbonylthreonyl]-N7-(2,3-dimethoxybenzoyl)norspermidine (97106-79-1) → N1,N4-bis[(L)-threonyl]-N7-(2,3-dimethoxybenzoyl)norspermidine dihydrobromide (96857-12-4)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1055/s-2007-965960

Reference yield:

N1-(tert-butoxycarbonyl)-N8-(2,3-dimethoxybenzoyl)norspermidine (943136-36-5) → N1,N4-bis[(L)-threonyl]-N7-(2,3-dimethoxybenzoyl)norspermidine dihydrobromide (96857-12-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 90 percent / BBr₃ / CH₂Cl₂ / 20 h / 20 °C

With boron tribromide; trifluoroacetic acid; In dichloromethane;

DOI:10.1055/s-2007-965960

upstream raw materials:

N₁,N₄-bis((L)-threonyl)-N₇-(2,3-dimethoxybenzoyl)norspermidine

N¹,N⁴-bis[(L)-N-tert-butoxycarbonylthreonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine

N¹-(tert-butoxycarbonyl)-N⁸-(2,3-dimethoxybenzoyl)norspermidine

2,3-dimethoxybenzoic acid

Downstream raw materials:

N-[3-(2,3-dihydroxybenzamido)propyl]-1,3-bis[2-(2-hydroxyphenyl)-trans-5-methyl-2-oxazoline-4-carboxamido]propane

N-[3-(2,3-dihydroxybenzamido)propyl]-1,3-bis[2-(2,3-dihydroxyphenyl)-trans-5-methyl-2-oxazoline-4-carboxamido]propane