(R)-(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol

Base Information

Chemical Name:(R)-(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol
CAS No.:922162-85-4
Molecular Formula:C₂₄H₃₄ClNO₃
Molecular Weight:419.992
Hs Code.:

Synonyms:(R)-(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol

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Chemical Property of (R)-(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol

Chemical Property:

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Technology Process of (R)-(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol

There total 7 articles about (R)-(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 922162-84-3
(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol

: 922162-86-5
(S)-(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol

: 922162-85-4
(R)-(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol

Guidance literature:: With Chiralcel OD column; In hexane; isopropyl alcohol; at 20 ℃; Resolution of racemate; HPLC conditions;
DOI:10.1016/j.bmc.2011.07.007

Reference yield:

: 922162-80-9
4-chloro-2-(2,2-dimethylpropoxy)-1-nitrobenzene

: 922162-86-5
(S)-(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol

: 922162-85-4
(R)-(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / ethyl acetate / 7 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Cooling with ice

3.1: sec.-butyllithium / tetrahydrofuran; hexane; cyclohexane / 0.5 h / -78 - 20 °C

3.2: 1.5 h / -78 - -50 °C

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 4 h / 0 - 50 °C

4.2: 0.08 h

5.1: Chiralcel OD column / hexane; isopropyl alcohol / 20 °C / Resolution of racemate; HPLC conditions

With dmap; hydrogen; sec.-butyllithium; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; hexane; dichloromethane; cyclohexane; ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1016/j.bmc.2011.07.007

Reference yield:

: 922162-81-0
4-chloro-2-(2,2-dimethylpropoxy)aniline

: 922162-86-5
(S)-(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol

: 922162-85-4
(R)-(5-chloro-3-(2,2-dimethylpropoxy)-2-[(2,2-dimethylpropyl)amino]phenyl)(2-methoxyphenyl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Cooling with ice

2.1: sec.-butyllithium / tetrahydrofuran; hexane; cyclohexane / 0.5 h / -78 - 20 °C

2.2: 1.5 h / -78 - -50 °C

3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 4 h / 0 - 50 °C

3.2: 0.08 h

4.1: Chiralcel OD column / hexane; isopropyl alcohol / 20 °C / Resolution of racemate; HPLC conditions

With dmap; sec.-butyllithium; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; hexane; dichloromethane; cyclohexane; isopropyl alcohol; toluene;
DOI:10.1016/j.bmc.2011.07.007