4-Boc-3-(2-carboxy-ethyl)-morpholine

Base Information

• Chemical Name: 4-Boc-3-(2-carboxy-ethyl)-morpholine
• CAS No.: 885274-05-5
• Molecular Formula: C₁₂H₂₁NO₅
• Molecular Weight: 259.302
• DSSTox Substance ID: DTXSID70698711
• Mol file: 885274-05-5.mol

Synonyms:885274-05-5;4-BOC-3-(2-CARBOXY-ETHYL)-MORPHOLINE;3-{4-[(tert-butoxy)carbonyl]morpholin-3-yl}propanoic acid;3-(4-(TERT-BUTOXYCARBONYL)MORPHOLIN-3-YL)PROPANOIC ACID;3-Morpholinepropanoicacid, 4-[(1,1-dimethylethoxy)carbonyl]-;3-[4-[(2-methylpropan-2-yl)oxycarbonyl]morpholin-3-yl]propanoic acid;3-[4-(TERT-BUTOXYCARBONYL)MORPHOLIN-3-YL]PROPANOIC ACID;3-(2-CARBOXY-ETHYL)-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;SCHEMBL15572580;DTXSID70698711;PNHILSYMESMDIU-UHFFFAOYSA-N;MFCD04114899;AB19202;CS-0237872;FT-0736384;EN300-1877314;3-(4-(TERT-BUTOXYCARBONYL)MORPHOLIN-3-YL)PROPANOICACID

Chemical Property of 4-Boc-3-(2-carboxy-ethyl)-morpholine

Chemical Property:

• PSA: 76.07000
• LogP: 1.42500
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 259.14197277
• Heavy Atom Count: 18
• Complexity: 310

Purity/Quality:

98%min ^*data from raw suppliers

4-Boc-3-(2-carboxy-ethyl)-morpholine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCOCC1CCC(=O)O

Technology Process of 4-Boc-3-(2-carboxy-ethyl)-morpholine

There total 1 articles about 4-Boc-3-(2-carboxy-ethyl)-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

cycl-isopropylidene malonate (2033-24-1) + tert-butyl 3-formylmorpholine-4-carboxylate (833474-06-9,1257850-86-4) → 3-(4-(tert-butoxycarbonyl)morpholin-3-yl)propanoic acid (885274-05-5)

Guidance literature:

With formic acid; triethylamine; at 0 - 100 ℃; for 5h; Cooling with ice;

upstream raw materials:

cycl-isopropylidene malonate

tert-butyl 3-formylmorpholine-4-carboxylate

Refernces

• 1、 -. "DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS". Paragraph 00220. . Retrieved 2014/03/25.