5-chloro-N-{4-[(dimethylamino)methyl]-2-methoxy-5-nitrophenyl}-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine

Base Information

Chemical Name:5-chloro-N-{4-[(dimethylamino)methyl]-2-methoxy-5-nitrophenyl}-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine
CAS No.:1453199-37-5
Molecular Formula:C₂₁H₂₀ClN₇O₃
Molecular Weight:453.888
Hs Code.:

Synonyms:5-chloro-N-{4-[(dimethylamino)methyl]-2-methoxy-5-nitrophenyl}-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine

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Chemical Property of 5-chloro-N-{4-[(dimethylamino)methyl]-2-methoxy-5-nitrophenyl}-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine

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Technology Process of 5-chloro-N-{4-[(dimethylamino)methyl]-2-methoxy-5-nitrophenyl}-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine

There total 5 articles about 5-chloro-N-{4-[(dimethylamino)methyl]-2-methoxy-5-nitrophenyl}-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1453199-36-4
4-[(dimethylamino)methyl]-2-methoxy-5-nitroaniline

: 882562-65-4
3-(2,5-dichloropyrimidin-4-yl)-imidazo[1,2-a]pyridine

: 1453199-37-5
5-chloro-N-{4-[(dimethylamino)methyl]-2-methoxy-5-nitrophenyl}-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine

Guidance literature:: With toluene-4-sulfonic acid; at 160 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm400822z

Reference yield:

: 457099-66-0
1-(3-methoxy-4-nitrophenyl)-N,N-dimethylmethanamine

: 1453199-37-5
5-chloro-N-{4-[(dimethylamino)methyl]-2-methoxy-5-nitrophenyl}-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

2: guanidine nitrate; sulfuric acid / 2 h / 0 - 10 °C

3: toluene-4-sulfonic acid / 2 h / 160 °C / Inert atmosphere

With sulfuric acid; palladium 10% on activated carbon; guanidine nitrate; hydrogen; toluene-4-sulfonic acid; In ethyl acetate;
DOI:10.1021/jm400822z

Reference yield:

: 68837-96-7
4-(chloromethyl)-2-methoxy-1-nitrobenzene

: 1453199-37-5
5-chloro-N-{4-[(dimethylamino)methyl]-2-methoxy-5-nitrophenyl}-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 3 h / 20 °C

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

3: guanidine nitrate; sulfuric acid / 2 h / 0 - 10 °C

4: toluene-4-sulfonic acid / 2 h / 160 °C / Inert atmosphere

With sulfuric acid; palladium 10% on activated carbon; guanidine nitrate; hydrogen; toluene-4-sulfonic acid; In ethyl acetate;
DOI:10.1021/jm400822z