7-(2-fluorobenzyloxy)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1-carboxamide

Base Information

• Chemical Name: 7-(2-fluorobenzyloxy)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1-carboxamide
• CAS No.: 1228929-06-3
• Molecular Formula: C₁₈H₁₅FN₄O₂
• Molecular Weight: 338.341

Synonyms:7-(2-fluorobenzyloxy)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1-carboxamide

Chemical Property of 7-(2-fluorobenzyloxy)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1-carboxamide

Chemical Property:

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Technology Process of 7-(2-fluorobenzyloxy)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1-carboxamide

There total 5 articles about 7-(2-fluorobenzyloxy)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.4%

ethyl 7-(2-fluorobenzyloxy)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1-carboxylate (1228928-92-4) → 7-(2-fluorobenzyloxy)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1-carboxamide (1228929-06-3)

Guidance literature:

With ammonia; In methanol; water; at 20 ℃; for 1h;

DOI:10.1007/s12272-010-0502-0

Reference yield:

6-(2-fluoro-benzyloxy)-3,4-dihydro-1H-quinolin-2-one (912283-07-9) → 7-(2-fluorobenzyloxy)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1-carboxamide (1228929-06-3)

Guidance literature:

Multi-step reaction with 4 steps

1: tetraphosphorus decasulfide; triethylamine / acetonitrile / 3 h / Reflux; Inert atmosphere

2: hydrazine hydrate / tetrahydrofuran / 1 h / 60 °C

3: 1 h / Reflux

4: ammonia / methanol; water / 1 h / 20 °C

With tetraphosphorus decasulfide; ammonia; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile;

DOI:10.1007/s12272-010-0502-0

Reference yield:

6-(2-fluoro-benzyloxy)-3,4-dihydro-1H-quinoline-2-thione → 7-(2-fluorobenzyloxy)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1-carboxamide (1228929-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / tetrahydrofuran / 1 h / 60 °C

2: 1 h / Reflux

3: ammonia / methanol; water / 1 h / 20 °C

With ammonia; hydrazine hydrate; In tetrahydrofuran; methanol; water;

DOI:10.1007/s12272-010-0502-0

upstream raw materials:

6-(2-fluoro-benzyloxy)-3,4-dihydro-1H-quinolin-2-one

C₁₆H₁₆FN₃O

ethyl 7-(2-fluorobenzyloxy)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1-carboxylate

3,4-dihydro-6-hydroxy-2(1H)-quinolinone

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