5-Bromopyrazine-2,3-diamine

Base Information

• Chemical Name: 5-Bromopyrazine-2,3-diamine
• CAS No.: 89123-58-0
• Molecular Formula: C4H5BrN4
• Molecular Weight: 189.014
• Hs Code.: 2933990090
• European Community (EC) Number: 635-837-6
• DSSTox Substance ID: DTXSID60378131
• Wikidata: Q72454014
• Mol file: 89123-58-0.mol

Synonyms:5-bromopyrazine-2,3-diamine;89123-58-0;2,3-Diamino-5-bromopyrazine;5-BROMO-2,3-DIAMINOPYRAZINE;2,3-Pyrazinediamine, 5-bromo-;MFCD06245575;5-Bromo-pyrazine-2,3-diamine;SCHEMBL165172;DTXSID60378131;CPYAUFLEMLTQAA-UHFFFAOYSA-N;BCP23253;BBL103870;STL557680;2,3-Diamino-5-bromopyrazine, 97%;AKOS001839472;AC-7340;CS-W008867;PB20156;PS-3087;SY005791;AM20070395;FT-0650452;EN300-112025;Q-103317

Chemical Property of 5-Bromopyrazine-2,3-diamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 212-216 °C (dec.)
• Refractive Index: 1.731
• Boiling Point: 357.1 °C at 760 mmHg
• PKA: 2.72±0.10(Predicted)
• Flash Point: 169.8 °C
• PSA: 77.82000
• Density: 1.956g/cm³
• LogP: 1.56590
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 187.96976
• Heavy Atom Count: 9
• Complexity: 98.6

Purity/Quality:

97% ^*data from raw suppliers

2,3-Diamino-5-bromopyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=C(C(=N1)N)N)Br
• Uses: 2,3-Diamino-5-bromopyrazine

Technology Process of 5-Bromopyrazine-2,3-diamine

There total 1 articles about 5-Bromopyrazine-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-amino-3,5-dibromopyrazine (24241-18-7) → 5-bromopyrazine-2,3-diamine (89123-58-0)

Guidance literature:

With ammonium hydroxide; In water; at 110 ℃; for 16h; sealed tube;

Reference yield: 100.0%

(3-((tert-butyldimethylsilyl)oxy)-4-cyclohexyl-2-fluorophenyl)boronic acid + 5-bromopyrazine-2,3-diamine (89123-58-0) → 5-(3-((tert-butyldimethylsilyl)oxy)-4-cyclohexyl-2-fluorophenyl)pyrazin-2-amine

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In water; toluene; at 80 ℃; for 16h;

Reference yield: 92.0%

5-bromopyrazine-2,3-diamine (89123-58-0) + dimethylglyoxal (431-03-8) → 2-bromo-6,7-dimethylpyrazino<2,3-b>pyrazine (56328-71-3)

Guidance literature:

In ethanol; at 20 ℃; for 6h;

upstream raw materials:

2-amino-3,5-dibromopyrazine

Downstream raw materials:

5-bromo-1-methyl-2-methylthio-1H-imidazo<4,5-b>pyrazine

6-bromo-4-methyl-2-methylthio-4H-imidazo<4,5-b>pyrazine

6-bromo-1-methyl-2-methylthio-1H-imidazo<4,5-b>pyrazine

5-bromo-1,3-dimethyl-1H-imidazo<4,5-b>pyrazine-2(3H)-thione