N-phthalimide l-valinyl chloride

Base Information

• Chemical Name: N-phthalimide l-valinyl chloride
• CAS No.: 5511-73-9
• Molecular Formula: C₁₃H₁₂ClNO₃
• Molecular Weight: 265.696
• Mol file: 5511-73-9.mol

Synonyms:N-phthalimide l-valinyl chloride

Chemical Property of N-phthalimide l-valinyl chloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phthalimide l-valinyl chloride

There total 2 articles about N-phthalimide l-valinyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → N-phthalimide l-valinyl chloride (5511-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.5 h / 150 - 180 °C

2: PCl₅ / benzene / 1 h

With phosphorus pentachloride; In benzene;

Reference yield:

phthalic anhydride (85-44-9) + L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → N-phthalimide l-valinyl chloride (5511-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / 24 h / Reflux

2: oxalyl dichloride / dichloromethane / 0.5 h / Reflux

With oxalyl dichloride; triethylamine; In dichloromethane; toluene;

Reference yield: 72.0%

N-phthalimide l-valinyl chloride (5511-73-9) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → N-(3,4-dimethoxyphenethyl)-2-(1,3-dioxoisoindolin-2-yl)-3-methylbutanamide

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h; Solvent; Reagent/catalyst;

DOI:10.21608/ejchem.2021.48494.2990

upstream raw materials:

phthalic anhydride

L-valine

Downstream raw materials:

(S)-(3,4-Dimethoxyphenyl)-(2-methyl-1-phthalimidopropyl)-keton

(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-hydroxy-3-methyl-N-p-tolyl-butyramide