(1S,2S)-1-(N-boc-amino)-1-(4-methylphenyl)-2-(4-chlorophenyl)-2-benzoyloxy ethane

Base Information

Chemical Name:(1S,2S)-1-(N-boc-amino)-1-(4-methylphenyl)-2-(4-chlorophenyl)-2-benzoyloxy ethane
CAS No.:1293372-57-2
Molecular Formula:C₂₇H₂₈ClNO₄
Molecular Weight:465.977
Hs Code.:

Synonyms:(1S,2S)-1-(N-boc-amino)-1-(4-methylphenyl)-2-(4-chlorophenyl)-2-benzoyloxy ethane

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Chemical Property of (1S,2S)-1-(N-boc-amino)-1-(4-methylphenyl)-2-(4-chlorophenyl)-2-benzoyloxy ethane

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Technology Process of (1S,2S)-1-(N-boc-amino)-1-(4-methylphenyl)-2-(4-chlorophenyl)-2-benzoyloxy ethane

There total 4 articles about (1S,2S)-1-(N-boc-amino)-1-(4-methylphenyl)-2-(4-chlorophenyl)-2-benzoyloxy ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1293372-55-0
(4S,5R)-N-boc-4-(4-methylphenyl)-5-(4-chlorophenyl)-[1,2,3]oxathiazolidine 2,2-dioxide

: 1863-63-4,21292-26-2,28271-83-2,143502-10-7
ammonium benzoate

: 1293372-57-2
(1S,2S)-1-(N-boc-amino)-1-(4-methylphenyl)-2-(4-chlorophenyl)-2-benzoyloxy ethane

Guidance literature:: (4S,5R)-N-boc-4-(4-methylphenyl)-5-(4-chlorophenyl)-[1,2,3]oxathiazolidine 2,2-dioxide; ammonium benzoate; In N,N-dimethyl-formamide; at 60 ℃; for 12h; Inert atmosphere;

With hydrogenchloride; water; In dichloromethane; at 25 ℃; for 6h; Inert atmosphere;
DOI:10.1039/c0cc05289b

Reference yield:

: 1293372-42-5
4-(4-methylphenyl)-5-(4-chlorophenyl)-5H-[1,2,3]oxathiazole 2,2-dioxide

: 1293372-57-2
(1S,2S)-1-(N-boc-amino)-1-(4-methylphenyl)-2-(4-chlorophenyl)-2-benzoyloxy ethane

Guidance literature:: Multi-step reaction with 3 steps

1.1: formic acid; RhCl[(R,R)-TsDPEN](C₅Me₅); triethylamine / ethyl acetate / 0.5 h / 25 °C / Inert atmosphere

2.1: dmap / dichloromethane / 1 h / 25 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

3.2: 6 h / 25 °C / Inert atmosphere

With dmap; formic acid; RhCl[(R,R)-TsDPEN](C₅Me₅); triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c0cc05289b

Reference yield:

: 1293372-54-9
(4S,5R)-4-(4-methylphenyl)-5-(4-chlorophenyl)-[1,2,3]oxathiazolidine 2,2-dioxide

: 1293372-57-2
(1S,2S)-1-(N-boc-amino)-1-(4-methylphenyl)-2-(4-chlorophenyl)-2-benzoyloxy ethane

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / dichloromethane / 1 h / 25 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

2.2: 6 h / 25 °C / Inert atmosphere

With dmap; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0cc05289b