Technology Process of 4-(3-methoxyphenyl)-3-methyl-4-oxobutanoic acid
There total 6 articles about 4-(3-methoxyphenyl)-3-methyl-4-oxobutanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(3-methoxyphenyl)propan-1-one; Glyoxilic acid;
With
sulfuric acid;
In
1,4-dioxane;
Reflux;
With
acetic acid; zinc;
In
water;
for 1h;
Reflux;
- Guidance literature:
-
With
hydrogenchloride;
In
water;
for 8h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C
2.1: tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: acetic acid; bromine / 1.5 h / 20 °C
4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 3 h / 0 - 20 °C
4.2: 2.5 h / 0 - 110 °C
5.1: hydrogenchloride / water / 8 h / Reflux
With
hydrogenchloride; bromine; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2012.08.121
