(20R)-5-methyl-19-nor-6-oxo-5β-pregn-9-ene-3β,20-diyl 3,20-dibenzoate

Base Information

• Chemical Name: (20R)-5-methyl-19-nor-6-oxo-5β-pregn-9-ene-3β,20-diyl 3,20-dibenzoate
• CAS No.: 218937-40-7
• Molecular Formula: C₃₅H₄₀O₅
• Molecular Weight: 540.7
• Mol file: 218937-40-7.mol

Synonyms:(20R)-5-methyl-19-nor-6-oxo-5β-pregn-9-ene-3β,20-diyl 3,20-dibenzoate

Chemical Property of (20R)-5-methyl-19-nor-6-oxo-5β-pregn-9-ene-3β,20-diyl 3,20-dibenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (20R)-5-methyl-19-nor-6-oxo-5β-pregn-9-ene-3β,20-diyl 3,20-dibenzoate

There total 2 articles about (20R)-5-methyl-19-nor-6-oxo-5β-pregn-9-ene-3β,20-diyl 3,20-dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(20R)-6-β-hydroxy-5-methyl-19-nor-5β-pregn-9-ene-3β,20-diyl 3,20-dibenzoate (218937-41-8) → (20R)-5-methyl-19-nor-6-oxo-5β-pregn-9-ene-3β,20-diyl 3,20-dibenzoate (218937-40-7)

Guidance literature:

With jones reagent; In acetone; toluene; for 0.833333h; Ambient temperature;

DOI:10.1135/cccc19981549

Reference yield:

(20R)-5-methyl-19-nor-5β-pregn-9-ene-3β,6β,20-triyl 6-acetate 3,20-dibenzoate (218937-39-4) → (20R)-5-methyl-19-nor-6-oxo-5β-pregn-9-ene-3β,20-diyl 3,20-dibenzoate (218937-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / HCl, H₂O / CHCl₃; methanol / 48 h / 40 °C

2: 86 percent / Jones reagent / acetone; toluene / 0.83 h / Ambient temperature

With hydrogenchloride; jones reagent; water; In methanol; chloroform; acetone; toluene;

DOI:10.1135/cccc19981549

Reference yield:

(20R)-5-methyl-19-nor-6-oxo-5β-pregn-9-ene-3β,20-diyl 3,20-dibenzoate (218937-40-7) → 5β-methyl-19-norpregn-9-ene-3,20-dione (130917-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / KOH, N₂H₄*H₂O / bis-(2-hydroxy-ethyl) ether / 1.) 140 deg C, 1 h, 2.) 200 deg C, 8 h

2: 13 percent / Jones reagent / acetone / 1.) -60 deg C, 5 min, 2.) -60 deg C to r.t., 45 min

With potassium hydroxide; jones reagent; hydrazine hydrate; In acetone; diethylene glycol;

DOI:10.1135/cccc19981549

upstream raw materials:

(20R)-6-β-hydroxy-5-methyl-19-nor-5β-pregn-9-ene-3β,20-diyl 3,20-dibenzoate

(20R)-5-methyl-19-nor-5β-pregn-9-ene-3β,6β,20-triyl 6-acetate 3,20-dibenzoate

Downstream raw materials:

5β-methyl-19-norpregn-9-ene-3,20-dione