Technology Process of (-)-(1R,2R)-2-allyl-1-isopropenylcyclohexanol
There total 1 articles about (-)-(1R,2R)-2-allyl-1-isopropenylcyclohexanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
isopropenylmagnesium bromide;
With
cerium(III) chloride;
In
tetrahydrofuran;
at -78 ℃;
for 3h;
(R)-2-allylcyclohexanone;
In
tetrahydrofuran;
at -78 ℃;
for 0.25h;
Further stages.;
DOI:10.1021/jo025927r
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C
1.2: tetrahydrofuran; hexane / -78 - -40 °C
2.1: NMO; OsO4; water / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / 20 °C
2.2: 58 percent / NaHCO3 / Pd(OAc)4 / toluene / 0.25 h / 20 °C
With
osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; water;
In
tetrahydrofuran; hexane; tert-butyl alcohol;
DOI:10.1021/jo025927r
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C
1.2: tetrahydrofuran; hexane / -78 - -40 °C
2.1: NMO; OsO4; water / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / 20 °C
2.2: 58 percent / NaHCO3 / Pd(OAc)4 / toluene / 0.25 h / 20 °C
3.1: s-butyllithium / cyclohexane; tetrahydrofuran / 3 h / -78 °C
3.2: cyclohexane; tetrahydrofuran / 0.25 h / -78 °C
With
osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; water; sec.-butyllithium;
In
tetrahydrofuran; hexane; cyclohexane; tert-butyl alcohol;
DOI:10.1021/jo025927r
