2-(3-chlorophenyl)-N-methyl-1,3-oxazol-4-amine

Base Information

• Chemical Name: 2-(3-chlorophenyl)-N-methyl-1,3-oxazol-4-amine
• CAS No.: 885273-40-5
• Molecular Formula: C10H9 Cl N2 O
• Molecular Weight: 208.64
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID00693057
• Wikidata: Q82622080
• Mol file: 885273-40-5.mol

Synonyms:2-(3-CHLORO-PHENYL)-OXAZOL-4-YL-METHYLAMINE;2-(3-chlorophenyl)-N-methyl-1,3-oxazol-4-amine;DTXSID00693057;AB27453

Chemical Property of 2-(3-chlorophenyl)-N-methyl-1,3-oxazol-4-amine

Chemical Property:

• PSA: 52.05000
• LogP: 3.15400
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 208.0403406
• Heavy Atom Count: 14
• Complexity: 191

Purity/Quality:

98%min ^*data from raw suppliers

(2-(3-Chlorophenyl)oxazol-4-yl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=COC(=N1)C2=CC(=CC=C2)Cl

Technology Process of 2-(3-chlorophenyl)-N-methyl-1,3-oxazol-4-amine

There total 1 articles about 2-(3-chlorophenyl)-N-methyl-1,3-oxazol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H11ClN2O3 (1133256-79-7) → C10H9ClN2O (885273-40-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Reflux;

DOI:10.1021/jf803632t

Reference yield:

3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl chloride (943982-60-3) + C10H9ClN2O (885273-40-5) → C19H12BrCl2N5O2

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; for 23h; Cooling with ice;

Reference yield:

C10H9ClN2O (885273-40-5) + 2-ethoxyethyl 2-cyano-3,3-dimethylthioacrylate (113210-88-1) → C19H20ClN3O4S (1133256-87-7)

Guidance literature:

In ethanol; Reflux;

DOI:10.1021/jf803632t

upstream raw materials:

C₁₈H₁₁ClN₂O₃

Downstream raw materials:

C₁₉H₂₀ClN₃O₄S

C₂₁H₂₄ClN₃O₄

Refernces