1-methyl-3-(4-(6-(methylcarbamoyl)pyridin-3-yl)phenyl)-5-(1,5,6,7-tetrahydroimidazo[4,5-f]isoindol-2-yl)-1H-pyrazol-4-yl diethylcarbamate

Base Information

Chemical Name:1-methyl-3-(4-(6-(methylcarbamoyl)pyridin-3-yl)phenyl)-5-(1,5,6,7-tetrahydroimidazo[4,5-f]isoindol-2-yl)-1H-pyrazol-4-yl diethylcarbamate
CAS No.:1197338-59-2
Molecular Formula:C₃₁H₃₂N₈O₃
Molecular Weight:564.647
Hs Code.:

Synonyms:1-methyl-3-(4-(6-(methylcarbamoyl)pyridin-3-yl)phenyl)-5-(1,5,6,7-tetrahydroimidazo[4,5-f]isoindol-2-yl)-1H-pyrazol-4-yl diethylcarbamate

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Chemical Property of 1-methyl-3-(4-(6-(methylcarbamoyl)pyridin-3-yl)phenyl)-5-(1,5,6,7-tetrahydroimidazo[4,5-f]isoindol-2-yl)-1H-pyrazol-4-yl diethylcarbamate

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Technology Process of 1-methyl-3-(4-(6-(methylcarbamoyl)pyridin-3-yl)phenyl)-5-(1,5,6,7-tetrahydroimidazo[4,5-f]isoindol-2-yl)-1H-pyrazol-4-yl diethylcarbamate

There total 12 articles about 1-methyl-3-(4-(6-(methylcarbamoyl)pyridin-3-yl)phenyl)-5-(1,5,6,7-tetrahydroimidazo[4,5-f]isoindol-2-yl)-1H-pyrazol-4-yl diethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₄₀N₈O₅

: 1197338-59-2
1-methyl-3-(4-(6-(methylcarbamoyl)pyridin-3-yl)phenyl)-5-(1,5,6,7-tetrahydroimidazo[4,5-f]isoindol-2-yl)-1H-pyrazol-4-yl diethylcarbamate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1197340-84-3
methyl 3-(4-bromophenyl)-4-(4-methoxybenzyloxy)-1H-pyrazole-5-carboxylate

: 1197338-59-2
1-methyl-3-(4-(6-(methylcarbamoyl)pyridin-3-yl)phenyl)-5-(1,5,6,7-tetrahydroimidazo[4,5-f]isoindol-2-yl)-1H-pyrazol-4-yl diethylcarbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium hydroxide monohydrate / N,N-dimethyl-formamide / 3 h / 20 °C / Ice bath

2.1: potassium carbonate / polyethylene supported palladium catalyst (FibreCat FC 1007) / ethanol; water / 0.25 h / 115 °C / Microwave irradiation

3.1: lithium hydroxide monohydrate; water / ethanol / 0.33 h / 115 °C / Microwave irradiation

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

5.1: acetic acid / 0.83 h / 150 °C / Microwave irradiation

6.1: trifluoroacetic acid / 0.5 h / 120 °C / Microwave irradiation

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

7.2: 2 h / 20 °C

8.1: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With lithium hydroxide monohydrate; potassium tert-butylate; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; polyethylene supported palladium catalyst (FibreCat FC 1007); In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1197340-73-0
methyl 3-(4-bromophenyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazole-5-carboxylate

: 1197338-59-2
1-methyl-3-(4-(6-(methylcarbamoyl)pyridin-3-yl)phenyl)-5-(1,5,6,7-tetrahydroimidazo[4,5-f]isoindol-2-yl)-1H-pyrazol-4-yl diethylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / polyethylene supported palladium catalyst (FibreCat FC 1007) / ethanol; water / 0.25 h / 115 °C / Microwave irradiation

2.1: lithium hydroxide monohydrate; water / ethanol / 0.33 h / 115 °C / Microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: acetic acid / 0.83 h / 150 °C / Microwave irradiation

5.1: trifluoroacetic acid / 0.5 h / 120 °C / Microwave irradiation

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

6.2: 2 h / 20 °C

7.1: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With lithium hydroxide monohydrate; potassium tert-butylate; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; polyethylene supported palladium catalyst (FibreCat FC 1007); In ethanol; dichloromethane; water; N,N-dimethyl-formamide;