2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [4-((S)-pyrrolidin-3-yloxy)-phenyl]-amide hydrochloride

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Chemical Name:2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [4-((S)-pyrrolidin-3-yloxy)-phenyl]-amide hydrochloride
CAS No.:1229419-42-4
Molecular Formula:C₂₁H₁₈F₃N₃O₃*ClH
Molecular Weight:453.848
Hs Code.:

Synonyms:2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [4-((S)-pyrrolidin-3-yloxy)-phenyl]-amide hydrochloride

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Chemical Property of 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [4-((S)-pyrrolidin-3-yloxy)-phenyl]-amide hydrochloride

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Technology Process of 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [4-((S)-pyrrolidin-3-yloxy)-phenyl]-amide hydrochloride

There total 3 articles about 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [4-((S)-pyrrolidin-3-yloxy)-phenyl]-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1085838-95-4
(S)-3-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenoxy}-pyrrolidine-1-carboxylic acid tert butyl ester

: 1229419-42-4
2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [4-((S)-pyrrolidin-3-yloxy)-phenyl]-amide hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃;

Reference yield:

: 1233860-29-1,218944-23-1
(S)-tert-butyl 3-(4-nitrophenoxy)pyrrolidine-1-carboxylate

: 1229419-42-4
2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [4-((S)-pyrrolidin-3-yloxy)-phenyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1.5 h / 2585.81 Torr

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h

2.2: 2.5 h / Cooling with ice

3.1: hydrogenchloride / diethyl ether; dichloromethane / 20 °C

With hydrogenchloride; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1229419-42-4
2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [4-((S)-pyrrolidin-3-yloxy)-phenyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1.5 h / 2585.81 Torr

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h

3.2: 2.5 h / Cooling with ice

4.1: hydrogenchloride / diethyl ether; dichloromethane / 20 °C

With hydrogenchloride; oxalyl dichloride; hydrogen; sodium hydride; N,N-dimethyl-formamide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; mineral oil;