3-(4-chlorophenyl)-N-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide

Base Information

• Chemical Name: 3-(4-chlorophenyl)-N-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide
• CAS No.: 1346911-17-8
• Molecular Formula: C₂₄H₂₁ClN₄O₃
• Molecular Weight: 448.909

Synonyms:3-(4-chlorophenyl)-N-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide

Chemical Property of 3-(4-chlorophenyl)-N-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide

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Technology Process of 3-(4-chlorophenyl)-N-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide

There total 3 articles about 3-(4-chlorophenyl)-N-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5,6-dimethoxy-2-[(pyridin-4-yl)methylene]-1-indanone (4803-74-1) + p-chlorophenylsemicarbazide (69194-89-4) → 3-(4-chlorophenyl)-N-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide (1346911-17-8)

Guidance literature:

With acetic acid; for 12h; Reflux;

DOI:10.1016/j.ejmech.2011.09.035

Reference yield:

pyridine-4-carbaldehyde (872-85-5) → 3-(4-chlorophenyl)-N-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide (1346911-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 4 h / 20 °C

2: acetic acid / 12 h / Reflux

With acetic acid; sodium hydroxide; In methanol; 1: Claisen-Schmidt condensation;

DOI:10.1016/j.ejmech.2011.09.035

Reference yield:

5,6-dimethoxy-1-indanone (2107-69-9) → 3-(4-chlorophenyl)-N-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide (1346911-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 4 h / 20 °C

2: acetic acid / 12 h / Reflux

With acetic acid; sodium hydroxide; In methanol; 1: Claisen-Schmidt condensation;

DOI:10.1016/j.ejmech.2011.09.035

upstream raw materials:

pyridine-4-carbaldehyde

5,6-dimethoxy-1-indanone

5,6-dimethoxy-2-[(pyridin-4-yl)methylene]-1-indanone

p-chlorophenylsemicarbazide

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