2-methyl-p-carbomethoxyhydrocinnamic acid

Base Information

• Chemical Name: 2-methyl-p-carbomethoxyhydrocinnamic acid
• CAS No.: 122594-17-6
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 122594-17-6.mol

Synonyms:2-methyl-p-carbomethoxyhydrocinnamic acid

Chemical Property of 2-methyl-p-carbomethoxyhydrocinnamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-p-carbomethoxyhydrocinnamic acid

There total 4 articles about 2-methyl-p-carbomethoxyhydrocinnamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzyl 2-methyl-p-carbomethoxycinnamate (122594-15-4) → 2-methyl-p-carbomethoxyhydrocinnamic acid (122594-17-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In isopropyl alcohol; for 7h; Ambient temperature;

DOI:10.1021/jm00163a035

Reference yield:

benzyl 2-methyl-3-hydroxy-p-carbomethoxyhydrocinnamate (122594-12-1) → 2-methyl-p-carbomethoxyhydrocinnamic acid (122594-17-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / POCl₃, pyridine / 1.) RT, 3 h, 2.) 100 deg C, 30 min

2: 87 percent / diazabicyclononene, pyridine / 1.25 h / 100 °C

3: 87 percent / H₂ / Pd/C (10percent) / propan-2-ol / 7 h / Ambient temperature

With pyridine; diazabicyclononene; hydrogen; trichlorophosphate; palladium on activated charcoal; In isopropyl alcohol;

DOI:10.1021/jm00163a035

Reference yield:

4-(2-Benzyloxycarbonyl-1-chloro-propyl)-benzoic acid methyl ester → 2-methyl-p-carbomethoxyhydrocinnamic acid (122594-17-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / diazabicyclononene, pyridine / 1.25 h / 100 °C

2: 87 percent / H₂ / Pd/C (10percent) / propan-2-ol / 7 h / Ambient temperature

With pyridine; diazabicyclononene; hydrogen; palladium on activated charcoal; In isopropyl alcohol;

DOI:10.1021/jm00163a035

upstream raw materials:

benzyl 2-methyl-p-carbomethoxycinnamate

benzyl 2-methyl-3-hydroxy-p-carbomethoxyhydrocinnamate

methyl 4-allylbenzoate

Downstream raw materials:

9-methyl-10-deazaminopterin diethyl ester

2-{4-[2-(2,4-Diamino-pteridin-6-yl)-propyl]-benzoylamino}-pentanedioic acid

1-amino-3-methyl-4-(p-carbomethoxyphenyl)-2-butanone hydrochloride

1-<(2',4'-diamino-5'-nitro-6'-pyrimidinyl)amino>-3-methyl-4-(p-carbomethoxyphenyl)-2-butanone