C₄₄H₅₀Cl₃NO₁₇

Base Information

• Chemical Name: C₄₄H₅₀Cl₃NO₁₇
• CAS No.: 1401413-73-7
• Molecular Formula: C₄₄H₅₀Cl₃NO₁₇
• Molecular Weight: 971.236
• Mol file: 1401413-73-7.mol

Synonyms:C₄₄H₅₀Cl₃NO₁₇

Chemical Property of C₄₄H₅₀Cl₃NO₁₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₅₀Cl₃NO₁₇

There total 12 articles about C₄₄H₅₀Cl₃NO₁₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C30H32Cl3NO8 (1401413-69-1) + 2,3,4,6-tetra-O-acetyl-D-galactopyranosyl trichloroacetimidate (74808-10-9,86520-63-0,87119-53-7,92052-29-4,121238-27-5,142831-80-9,127061-80-7) → C44H50Cl3NO17 (1401413-73-7)

Guidance literature:

C₃₀H₃₂Cl₃NO₈; 2,3,4,6-tetra-O-acetyl-D-galactopyranosyl trichloroacetimidate; In dichloromethane; at 20 ℃; for 0.5h; Molecular sieve;

trifluorormethanesulfonic acid; In dichloromethane; at -70 - -20 ℃; for 1h;

Reference yield:

D-glucosamine hydrochloride (14131-63-6) → C44H50Cl3NO17 (1401413-73-7)

Guidance literature:

Multi-step reaction with 12 steps

1.1: sodium hydrogencarbonate / water / 0.5 h / 20 °C

1.2: 4.5 h / 20 °C

2.1: pyridine / 0 - 20 °C

3.1: boron trifluoride diethyl etherate / dichloromethane / 0 - 20 °C

4.1: zinc; acetic acid / dichloromethane; methanol / 1 h / 0 - 20 °C / Inert atmosphere

5.1: sodium methylate / dichloromethane; methanol / 2 h / 20 °C

5.2: pH ~ 7

6.1: potassium carbonate; triflic azide / zinc(II) chloride / dichloromethane; water; methanol / 20 °C

7.1: camphorsulfonic acid / toluene / 2 h / 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

9.1: trifluorormethanesulfonic acid; triethylsilane / dichloromethane / 1 h / -78 °C

10.1: sodium hydroxide; trimethylphosphane / water; tetrahydrofuran

11.1: sodium hydrogencarbonate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

12.1: dichloromethane / 0.5 h / 20 °C / Molecular sieve

12.2: 1 h / -70 - -20 °C

With pyridine; triethylsilane; trifluorormethanesulfonic acid; triflic azide; boron trifluoride diethyl etherate; sodium methylate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; sodium hydroxide; zinc; trimethylphosphane; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

1,3,4,6-tetra-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranose (122210-05-3) → C44H50Cl3NO17 (1401413-73-7)

Guidance literature:

Multi-step reaction with 10 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 0 - 20 °C

2.1: zinc; acetic acid / dichloromethane; methanol / 1 h / 0 - 20 °C / Inert atmosphere

3.1: sodium methylate / dichloromethane; methanol / 2 h / 20 °C

3.2: pH ~ 7

4.1: potassium carbonate; triflic azide / zinc(II) chloride / dichloromethane; water; methanol / 20 °C

5.1: camphorsulfonic acid / toluene / 2 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

7.1: trifluorormethanesulfonic acid; triethylsilane / dichloromethane / 1 h / -78 °C

8.1: sodium hydroxide; trimethylphosphane / water; tetrahydrofuran

9.1: sodium hydrogencarbonate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

10.1: dichloromethane / 0.5 h / 20 °C / Molecular sieve

10.2: 1 h / -70 - -20 °C

With triethylsilane; trifluorormethanesulfonic acid; triflic azide; boron trifluoride diethyl etherate; sodium methylate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; sodium hydroxide; zinc; trimethylphosphane; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

upstream raw materials:

β-D-galactose peracetate

D-glucosamine hydrochloride

C₃₀H₃₂Cl₃NO₈

2,3,4,6-tetra-O-acetyl-D-galactopyranosyl trichloroacetimidate