2-{3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

Base Information

Chemical Name:2-{3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide
CAS No.:1132817-32-3
Molecular Formula:C₂₆H₂₄F₃N₅O₂
Molecular Weight:495.504
Hs Code.:

Synonyms:2-{3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

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Chemical Property of 2-{3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

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Technology Process of 2-{3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

There total 7 articles about 2-{3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1132817-67-4
3-[4-(4-methyl-1H-imidazol-1-yl)phenyl]-1,4-diazaspiro[4.4]non-3-en-2-one

: 351-38-2
N-chloroacetyl-3-(trifluoromethyl)aniline

: 1132817-32-3
2-{3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

: 1132817-33-4
2-{3-[4-(4-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

Guidance literature:: With potassium hydroxide; In 1-methyl-pyrrolidin-2-one; water; at 25 ℃; for 6h; Large scale reaction;
DOI:10.1021/op100210s

Reference yield:

: 1132817-67-4
3-[4-(4-methyl-1H-imidazol-1-yl)phenyl]-1,4-diazaspiro[4.4]non-3-en-2-one

: 1132817-68-5
3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-1,4-diazaspiro[4.4]non-3-en-2-one

: 25625-57-4
2-bromo-N-(3′-(trifluoromethyl)phenyl)acetamide

: 1132817-32-3
2-{3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

: 1132817-33-4
2-{3-[4-(4-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

Guidance literature:: 3-[4-(4-methyl-1H-imidazol-1-yl)phenyl]-1,4-diazaspiro[4.4]non-3-en-2-one; 3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-1,4-diazaspiro[4.4]non-3-en-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

2-bromo-N-(3′-(trifluoromethyl)phenyl)acetamide; In N,N-dimethyl-formamide; at 0 - 20 ℃; Product distribution / selectivity;

Reference yield:

: 3-(4-bromophenyl)-1,4-diazaspiro[4.4]non-3-en-2-one

: 1132817-32-3
2-{3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

: 1132817-33-4
2-{3-[4-(4-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 36 h / 130 °C / Large scale reaction

2: potassium hydroxide / 1-methyl-pyrrolidin-2-one; water / 6 h / 25 °C / Large scale reaction

With copper(l) iodide; potassium carbonate; potassium hydroxide; In 1-methyl-pyrrolidin-2-one; water; dimethyl sulfoxide; 1: Ullmann condensation / 2: Ullmann condensation;
DOI:10.1021/op100210s