tert-butyl (2-(4-(chloromethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

Base Information

Chemical Name:tert-butyl (2-(4-(chloromethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate
CAS No.:953434-83-8
Molecular Formula:C₂₃H₂₃ClN₂O₃S
Molecular Weight:442.966
Hs Code.:

Synonyms:tert-butyl (2-(4-(chloromethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

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Chemical Property of tert-butyl (2-(4-(chloromethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

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Technology Process of tert-butyl (2-(4-(chloromethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

There total 10 articles about tert-butyl (2-(4-(chloromethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 335255-43-1
tert-butyl 2-amino-4-(thiophen-2-yl)phenylcarbamate

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 953434-83-8
tert-butyl (2-(4-(chloromethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1002/bkcs.12254

Reference yield: 65.0%

: 3437-95-4,149762-92-5
2-Iodothiophene

: 1473358-19-8
C₂₅H₃₂BClN₂O₅

: 953434-83-8
tert-butyl (2-(4-(chloromethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

Guidance literature:: With potassium fluoride; palladium; In methanol; for 5h; Reflux;
DOI:10.5012/bkcs.2013.34.8.2249

Reference yield:

: 327046-79-7
tert-butyl (4-bromo-2-nitrophenyl)carbamate

: 953434-83-8
tert-butyl (2-(4-(chloromethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 80 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C / 2585.81 Torr

3: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4: palladium; potassium fluoride / methanol / 5 h / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; palladium 10% on activated carbon; hydrogen; potassium acetate; palladium; triethylamine; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; 4: |Suzuki Coupling;
DOI:10.5012/bkcs.2013.34.8.2249