2-(4-Methoxy-phenylamino)-7-methyl-3,3-diphenyl-3H-benzo[de][1,6]naphthyridine-5-carboxylic acid ethyl ester

Base Information

Chemical Name:2-(4-Methoxy-phenylamino)-7-methyl-3,3-diphenyl-3H-benzo[de][1,6]naphthyridine-5-carboxylic acid ethyl ester
CAS No.:137834-57-2
Molecular Formula:C₃₄H₂₉N₃O₃
Molecular Weight:527.623
Hs Code.:

Synonyms:2-(4-Methoxy-phenylamino)-7-methyl-3,3-diphenyl-3H-benzo[de][1,6]naphthyridine-5-carboxylic acid ethyl ester

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Chemical Property of 2-(4-Methoxy-phenylamino)-7-methyl-3,3-diphenyl-3H-benzo[de][1,6]naphthyridine-5-carboxylic acid ethyl ester

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Technology Process of 2-(4-Methoxy-phenylamino)-7-methyl-3,3-diphenyl-3H-benzo[de][1,6]naphthyridine-5-carboxylic acid ethyl ester

There total 7 articles about 2-(4-Methoxy-phenylamino)-7-methyl-3,3-diphenyl-3H-benzo[de][1,6]naphthyridine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137834-53-8
C₃₈H₃₄N₃O₃P

: 525-06-4
diphenyl ketene

: 137834-57-2
2-(4-Methoxy-phenylamino)-7-methyl-3,3-diphenyl-3H-benzo[de][1,6]naphthyridine-5-carboxylic acid ethyl ester

Guidance literature:: In toluene; Yield given; 1) room temperature, 30 min, 2) 160 deg C, 24 h;
DOI:10.1021/jo00051a007

Reference yield:

: 1975-52-6
5-nitro-o-toluic acid

: 137834-57-2
2-(4-Methoxy-phenylamino)-7-methyl-3,3-diphenyl-3H-benzo[de][1,6]naphthyridine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / 10percent Pd/C

2: LiAlH₄

3: 2) sodium azide

4: pyridinium chlorochromate

6: triphenylphosphine

7: CH₂Cl₂ / 5 h / Ambient temperature; other heterocumulenes

8: 160 - 170 °C

With lithium aluminium tetrahydride; sodium azide; hydrogen; triphenylphosphine; pyridinium chlorochromate; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/S0040-4039(00)92391-8

Reference yield:

: 111437-10-6
3-(hydroxymethyl)-4-methylaniline

: 137834-57-2
2-(4-Methoxy-phenylamino)-7-methyl-3,3-diphenyl-3H-benzo[de][1,6]naphthyridine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1) H₂SO₄, NaNO₂, 2) NaN₃ / 1) H₂O, 0 deg C, 30 min, 2) 3 h

2: pyridinium chlorochromate / CH₂Cl₂ / 4 h / Ambient temperature

3: 67 percent / Na, EtOH / 5 h / -15 °C

4: 91 percent / diethyl ether / 12 h / Ambient temperature

5: 83 percent / CH₂Cl₂ / Ambient temperature; 1 equiv of isocyanate (reaction with 2 equiv of isocyanate, toluene, r.t., 1 h, then 160 deg, 1h leads directly to pyrido<2,3,4-de>quinazolines); sequential treatment with isocyanate and ketene or aldehydes and isocyanates; reaction with CS₂

6: toluene / 1) room temperature, 30 min, 2) 160 deg C, 24 h

With sodium azide; ethanol; sulfuric acid; sodium; pyridinium chlorochromate; sodium nitrite; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo00051a007