N-{2,4-dichloro-3-[6-hydroxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl}-2,2-dimethyl-propionamide

Base Information

Chemical Name:N-{2,4-dichloro-3-[6-hydroxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl}-2,2-dimethyl-propionamide
CAS No.:1360702-58-4
Molecular Formula:C₂₁H₂₁Cl₂F₂N₅O₄
Molecular Weight:516.332
Hs Code.:

Synonyms:N-{2,4-dichloro-3-[6-hydroxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl}-2,2-dimethyl-propionamide

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Chemical Property of N-{2,4-dichloro-3-[6-hydroxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl}-2,2-dimethyl-propionamide

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Technology Process of N-{2,4-dichloro-3-[6-hydroxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl}-2,2-dimethyl-propionamide

There total 22 articles about N-{2,4-dichloro-3-[6-hydroxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl}-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360702-57-3
N-{2,4-Dichloro-3-[6-methoxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]benzyl)-2,2-dimethyl-propionamide

: 1360702-58-4
N-{2,4-Dichloro-3-[6-hydroxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]benzyl)-2,2-dimethyl-propionamide

Guidance literature:: N-{2,4-Dichloro-3-[6-methoxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]benzyl)-2,2-dimethyl-propionamide; With sodium hydroxide; In methanol; at 20 ℃; Reflux;

With hydrogenchloride; In methanol; water;

Reference yield:

: 1360702-57-3
N-{2,4-dichloro-3-[6-methoxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl}-2,2-dimethyl-propionamide

: 1360702-58-4
N-{2,4-dichloro-3-[6-hydroxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl}-2,2-dimethyl-propionamide

Guidance literature:: N-{2,4-dichloro-3-[6-methoxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl}-2,2-dimethyl-propionamide; With water; sodium hydroxide; In methanol; for 0.75h; Reflux;

With hydrogenchloride; In water;

Reference yield:

: 1360624-03-8
N-(3-nitro-2,4-dichloro-benzyl)-2,2,2-trifluoroacetamide

: 1360702-58-4
N-{2,4-dichloro-3-[6-hydroxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl}-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide; methanol / 4 h / Reflux

2: triethylamine / tetrahydrofuran

3: hydrogen / Ra-Ni / tetrahydrofuran / 7 h / 2585.81 Torr

4: 1,4-dioxane / 8 h / Reflux

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / Reflux

6: sodium hydroxide; water / methanol / 0.75 h / Reflux

With methanol; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; Ra-Ni; In tetrahydrofuran; 1,4-dioxane; methanol; acetonitrile;