5,5-bis[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-3-(methylethylidene)-4,4-dihydrofuran-2-one

Base Information

Chemical Name:5,5-bis[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-3-(methylethylidene)-4,4-dihydrofuran-2-one
CAS No.:528881-73-4
Molecular Formula:C₄₁H₅₀O₄Si₂
Molecular Weight:663.017
Hs Code.:

Synonyms:5,5-bis[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-3-(methylethylidene)-4,4-dihydrofuran-2-one

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Chemical Property of 5,5-bis[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-3-(methylethylidene)-4,4-dihydrofuran-2-one

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Technology Process of 5,5-bis[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-3-(methylethylidene)-4,4-dihydrofuran-2-one

There total 5 articles about 5,5-bis[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-3-(methylethylidene)-4,4-dihydrofuran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5,5-bis[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-3-(1-hydroxy-isopropyl)-3,4,5-trihydrofuran-2-one

: 528881-73-4
5,5-bis[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-3-(methylethylidene)-4,4-dihydrofuran-2-one

Guidance literature:: With pyridine; trichlorophosphate; at 0 - 20 ℃;
DOI:10.1021/jm020476o

Reference yield:

: 172843-14-0
5-bis<<(tert-butyldiphenylsilyl)oxy>methyl>tetrahydro-2-furanone

: 528881-73-4
5,5-bis[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-3-(methylethylidene)-4,4-dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran / 0.35 h

2.1: POCl₃; pyridine / 0 - 20 °C

With pyridine; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran;
DOI:10.1021/jm020476o

Reference yield:

: 172843-10-6
1,3-bis[[tert-butyl(diphenyl)silyl]oxy]propan-2-one

: 528881-73-4
5,5-bis[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-3-(methylethylidene)-4,4-dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; diethyl ether / 1.17 h / 0 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 6 h / -78 - 20 °C / Inert atmosphere

2.2: 46 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

3.2: 0.5 h

4.1: triethylamine; methanesulfonyl chloride / dichloromethane / 2.83 h / 0 - 20 °C

4.2: 2 h / 0 - 20 °C

With dimethylsulfide borane complex; methanesulfonyl chloride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane;