3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

Base Information

Chemical Name:3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide
CAS No.:1374454-14-4
Molecular Formula:C₂₈H₂₄ClN₅O₅
Molecular Weight:545.982
Hs Code.:

Synonyms:3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

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Chemical Property of 3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

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Technology Process of 3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

There total 6 articles about 3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1160936-49-1
1-{[(3-methoxyisoxazol-5-yl)carbonyl]amino}cyclopropanecarboxylic acid

: 1374454-17-7
4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzylamine

: 1374454-14-4
3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: 28737-32-8
3-chloro-1H-indole-2-carboxylic acid

: 1374454-14-4
3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Reflux

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: Burgess Reagent / tetrahydrofuran / 0.28 h / 120 °C / Inert atmosphere; microwave oven

3.1: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 144 h / 20 °C / Molecular sieve

4.1: hydrogenchloride / ethyl acetate; methoxybenzene / 1.5 h / 0 - 20 °C

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 48 h / 20 °C

With hydrogenchloride; oxalyl dichloride; Burgess Reagent; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; copper diacetate; In tetrahydrofuran; dichloromethane; ethyl acetate; methoxybenzene; N,N-dimethyl-formamide;

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 1374454-14-4
3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-chloro-succinimide / acetonitrile / 5 h / Reflux

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Reflux

2.2: 1 h / 0 - 20 °C / Inert atmosphere

3.1: Burgess Reagent / tetrahydrofuran / 0.28 h / 120 °C / Inert atmosphere; microwave oven

4.1: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 144 h / 20 °C / Molecular sieve

5.1: hydrogenchloride / ethyl acetate; methoxybenzene / 1.5 h / 0 - 20 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 48 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; oxalyl dichloride; Burgess Reagent; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; copper diacetate; In tetrahydrofuran; dichloromethane; ethyl acetate; methoxybenzene; N,N-dimethyl-formamide; acetonitrile;